PMID- 23984681
OWN - NLM
STAT- MEDLINE
DCOM- 20140707
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 15
IP  - 1
DP  - 2013 Aug 28
TI  - Early detection of subclinical ventricular deterioration in aortic stenosis with 
      cardiovascular magnetic resonance and echocardiography.
PG  - 72
LID - 10.1186/1532-429X-15-72 [doi]
AB  - BACKGROUND: Severe aortic stenosis (AS) patients with late gadolinium enhancement 
      (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) 
      systolic dysfunction are known to have worse outcome. We aimed to investigate 
      whether LGE on CMR would be useful in early detection of subclinical LV 
      structural and functional derangements in AS patients. METHODS: 118 patients with 
      moderate to severe AS were prospectively enrolled. Echocardiography and CMR 
      images were taken and the patients were divided into groups according to the 
      presence/absence of LGE and of LV systolic dysfunction (LV ejection fraction (EF) 
      <50%). The stiffness of LV was calculated based on Doppler and CMR measurements. 
      RESULTS: Patients were grouped into either group 1, no LGE and normal LVEF, group 
      2, LGE but normal LVEF and group 3, LGE with depressed LVEF. There was a 
      significant trend towards increasing LV volumes, worsening of LV diastolic 
      function (E/e', diastolic elastance), systolic function (end-systolic elastance) 
      and LV hypertrophy between the three groups, which coincided with worsening 
      functional capacity (all p-value < 0.001 for trend). Also, significant 
      differences in the above parameters were noted between group 1 and 2 (E/e', 14.6 
      +/- 4.3 (mean +/- standard deviation) in group 1 vs. 18.2 +/- 9.4 in group 2; 
      end-systolic elastance, 3.24 +/- 2.31 in group 1 vs. 2.38 +/- 1.16 in group 2, all 
      p-value < 0.05). The amount of myocardial fibrosis on CMR correlated with 
      parameters of diastolic (diastolic elastance, Spearman's rho = 0.256, p-value = 
      0.005) and systolic function (end-systolic elastance, Spearman's rho = -0.359, 
      p-value < 0.001). CONCLUSIONS: These findings demonstrate the usefulness of CMR 
      for early detection of subclinical LV structural and functional deterioration in 
      AS patients.
FAU - Lee, Seung-Pyo
AU  - Lee SP
AD  - Cardiovascular Center, Seoul National University Hospital, 101 Daehak-ro, 
      Jongro-gu, Seoul 110-744, Korea. tyche.park@gmail.com.
FAU - Park, Sung-Ji
AU  - Park SJ
FAU - Kim, Yong-Jin
AU  - Kim YJ
FAU - Chang, Sung-A
AU  - Chang SA
FAU - Park, Eun-Ah
AU  - Park EA
FAU - Kim, Hyung-Kwan
AU  - Kim HK
FAU - Lee, Whal
AU  - Lee W
FAU - Lee, Sang-Chol
AU  - Lee SC
FAU - Park, Seung Woo
AU  - Park SW
FAU - Sohn, Dae-Won
AU  - Sohn DW
FAU - Choe, Yeon-Hyeon
AU  - Choe YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130828
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/*complications
MH  - Asymptomatic Diseases
MH  - Contrast Media
MH  - Diastole
MH  - Early Diagnosis
MH  - *Echocardiography, Doppler
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnosis/diagnostic imaging/physiopathology
MH  - *Ventricular Function, Left
PMC - PMC3766067
EDAT- 2013/08/30 06:00
MHDA- 2014/07/08 06:00
PMCR- 2013/08/28
CRDT- 2013/08/30 06:00
PHST- 2013/03/09 00:00 [received]
PHST- 2013/08/08 00:00 [accepted]
PHST- 2013/08/30 06:00 [entrez]
PHST- 2013/08/30 06:00 [pubmed]
PHST- 2014/07/08 06:00 [medline]
PHST- 2013/08/28 00:00 [pmc-release]
AID - S1097-6647(23)00788-3 [pii]
AID - 1532-429X-15-72 [pii]
AID - 10.1186/1532-429X-15-72 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2013 Aug 28;15(1):72. doi: 10.1186/1532-429X-15-72.