PMID- 23985898
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20240109
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 11
IP  - 9
DP  - 2013 Aug 27
TI  - Apo-9'-fucoxanthinone, isolated from Sargassum muticum, inhibits CpG-induced 
      inflammatory response by attenuating the mitogen-activated protein kinase 
      pathway.
PG  - 3272-87
LID - 10.3390/md11093272 [doi]
AB  - Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in 
      Korea. This report was designed to evaluate the anti-inflammatory properties of 
      apo-9'-fucoxanthinone (APO-9') isolated from S. muticum on pro-inflammatory 
      cytokine production. S. muticum extract (SME) exhibited significant inhibitory 
      effects on pro-inflammatory cytokine production in bone marrow-derived 
      macrophages (BMDMs) and dendritic cells (BMDCs). APO-9' pre-treatment in the CpG 
      DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect 
      on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-alpha production 
      with IC50 values ranging from 5.31 to 13.79. It exhibited a strong inhibitory 
      effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter 
      activity. APO-9' pre-treatment exhibited significant inhibition of CpG 
      DNA-induced production of inducible nitric oxide synthase. Taken together, these 
      data suggest that SME and APO-9' have a significant anti-inflammatory property 
      and warrant further studies concerning the potentials of SME and APO-9' for 
      medicinal use.
FAU - Chae, Doobyeong
AU  - Chae D
AD  - School of Medicine, Jeju National University, Jeju 690-756, Korea.
FAU - Manzoor, Zahid
AU  - Manzoor Z
FAU - Kim, Sung Chun
AU  - Kim SC
FAU - Kim, Sohyun
AU  - Kim S
FAU - Oh, Tae-Heon
AU  - Oh TH
FAU - Yoo, Eun-Sook
AU  - Yoo ES
FAU - Kang, Hee-Kyoung
AU  - Kang HK
FAU - Hyun, Jin-Won
AU  - Hyun JW
FAU - Lee, Nam Ho
AU  - Lee NH
FAU - Ko, Mi-Hee
AU  - Ko MH
FAU - Koh, Young-Sang
AU  - Koh YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130827
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (I-kappa B Proteins)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (NFKBIA protein, human)
RN  - 0 (Nfkbia protein, mouse)
RN  - 0 (Plant Extracts)
RN  - 0 (Transcription Factor AP-1)
RN  - 139874-52-5 (NF-KappaB Inhibitor alpha)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, mouse)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*chemistry/*pharmacology
MH  - Cell Line
MH  - CpG Islands/drug effects
MH  - HEK293 Cells
MH  - Humans
MH  - I-kappa B Proteins/metabolism
MH  - Interleukin-2/metabolism
MH  - Interleukin-6/metabolism
MH  - Macrophages/drug effects/metabolism
MH  - Mice
MH  - Mitogen-Activated Protein Kinases
MH  - NF-KappaB Inhibitor alpha
MH  - NF-kappa B/metabolism
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Phaeophyceae/chemistry
MH  - Phosphorylation/drug effects
MH  - Plant Extracts/*chemistry/*pharmacology
MH  - Sargassum/*chemistry
MH  - Signal Transduction/drug effects
MH  - Transcription Factor AP-1/metabolism
PMC - PMC3806467
EDAT- 2013/08/30 06:00
MHDA- 2014/05/07 06:00
PMCR- 2013/09/01
CRDT- 2013/08/30 06:00
PHST- 2013/07/18 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/08/20 00:00 [accepted]
PHST- 2013/08/30 06:00 [entrez]
PHST- 2013/08/30 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - md11093272 [pii]
AID - marinedrugs-11-03272 [pii]
AID - 10.3390/md11093272 [doi]
PST - epublish
SO  - Mar Drugs. 2013 Aug 27;11(9):3272-87. doi: 10.3390/md11093272.