PMID- 23986892
OWN - NLM
STAT- MEDLINE
DCOM- 20140813
LR  - 20221207
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Print)
IS  - 1239-9736 (Linking)
VI  - 72
DP  - 2013
TI  - The frequency of HLA alleles in a population of Inuit women of northern Quebec.
LID - 10.3402/ijch.v72i0.21350 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) alleles code for proteins that are 
      involved in the recognition of foreign antigens and activation of the immune 
      system. The frequency of HLA alleles varies across different populations. 
      OBJECTIVE: To describe the frequency of HLA alleles in a population of Inuit 
      women of Nunavik, Quebec, Canada. DESIGN: A cohort of women was recruited from 4 
      different communities between January 2002 and December 2007. HLA-B*07, 
      HLA-DQB1*03, DQB1*06:02, DRB1*13 and DRB1*15:01 alleles were typed by PCR 
      sequence-specific primers (PCR-SSP) and HLA-E and G alleles were type by 
      DNA-sequencing procedures. RESULTS: We obtained data on 524 participants. The 
      most frequent HLA alleles in this population were HLA-E*01:03, HLA-G*01:04:01 and 
      HLA-DQB1*03, and they were found in 89, 75 and 94% of the population, 
      respectively. CONCLUSIONS: The distribution of HLA alleles in Nunavik, Quebec is 
      unique when compared to other populations in Canada or around the world.
FAU - Metcalfe, Stephanie
AU  - Metcalfe S
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Quebec, Canada.
FAU - Roger, Michel
AU  - Roger M
FAU - Faucher, Marie-Claude
AU  - Faucher MC
FAU - Coutlee, Francois
AU  - Coutlee F
FAU - Franco, Eduardo L
AU  - Franco EL
FAU - Brassard, Paul
AU  - Brassard P
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130805
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B*07 antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency/*genetics
MH  - HLA Antigens/*genetics
MH  - HLA-B7 Antigen/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - Haplotypes/genetics
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Inuit/*genetics
MH  - Middle Aged
MH  - Quebec/epidemiology
MH  - Young Adult
PMC - PMC3754547
OTO - NOTNLM
OT  - Canada
OT  - Inuit
OT  - Nunavik
OT  - human leukocyte antigen
EDAT- 2013/08/30 06:00
MHDA- 2014/08/15 06:00
PMCR- 2013/01/01
CRDT- 2013/08/30 06:00
PHST- 2013/08/30 06:00 [entrez]
PHST- 2013/08/30 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 21350 [pii]
AID - 10.3402/ijch.v72i0.21350 [doi]
PST - epublish
SO  - Int J Circumpolar Health. 2013 Aug 5;72. doi: 10.3402/ijch.v72i0.21350. 
      eCollection 2013.