PMID- 23987384
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20130830
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 98
IP  - 1
DP  - 2013 Oct 15
TI  - Cell culture and characterization of cross-linked poly(vinyl alcohol)-g-starch 3D 
      scaffold for tissue engineering.
PG  - 574-80
LID - S0144-8617(13)00616-4 [pii]
LID - 10.1016/j.carbpol.2013.06.020 [doi]
AB  - The research goal of this experiment is chemically to cross-link poly(vinyl 
      alcohol) (PVA) and starch to form a 3D scaffold that is effective water 
      absorbent, has a stable structure, and supports cell growth. PVA and starch can 
      be chemically cross-linked to form a PVA-g-starch 3D scaffold polymer, as 
      observed by Fourier transform infrared spectroscopy (FTIR), with an absorbency of 
      up to 800%. Tensile testing reveals that, as the amount of starch increases, the 
      strength of the 3D scaffold strength reaches 4x10(-2) MPa. Scanning electron 
      microscope (SEM) observations of the material reveal that the 3D scaffold is 
      highly porous formed using a homogenizer at 500 rpm. In an enzymatic degradation, 
      the 3D scaffold was degraded by various enzymes at a rate of up to approximately 
      30-60% in 28 days. In vitro tests revealed that cells proliferate and grow in the 
      3D scaffold material. Energy dispersive spectrometer (EDS) analysis further 
      verified that the bio-compatibility of this scaffold.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Hsieh, Wen-Chuan
AU  - Hsieh WC
AD  - Department of Biological Science and Technology, I-Shou University, Kaohsiung 
      82445, Taiwan, ROC. wenchuan@isu.edu.tw
FAU - Liau, Jiun-Jia
AU  - Liau JJ
LA  - eng
PT  - Journal Article
DEP - 20130620
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Biocompatible Materials)
RN  - 9002-89-5 (Polyvinyl Alcohol)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry/*pharmacology
MH  - Materials Testing
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Polyvinyl Alcohol/*chemistry/*pharmacology
MH  - Porosity
MH  - Regenerative Medicine
MH  - Tensile Strength
MH  - *Tissue Engineering/economics
MH  - Tissue Scaffolds/*chemistry/economics
OTO - NOTNLM
OT  - 3D scaffold
OT  - Biodegradation
OT  - Cell culture
OT  - Cross-linking
OT  - PVA-g-starch
EDAT- 2013/08/31 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/08/31 06:00
PHST- 2013/03/15 00:00 [received]
PHST- 2013/06/10 00:00 [revised]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - S0144-8617(13)00616-4 [pii]
AID - 10.1016/j.carbpol.2013.06.020 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2013 Oct 15;98(1):574-80. doi: 10.1016/j.carbpol.2013.06.020. 
      Epub 2013 Jun 20.