PMID- 23989258 OWN - NLM STAT- MEDLINE DCOM- 20140320 LR - 20180816 IS - 1108-7161 (Print) IS - 1108-7161 (Linking) VI - 13 IP - 3 DP - 2013 Sep TI - Impact of exercise training on neuroplasticity-related growth factors in adolescents. PG - 368-71 AB - OBJECTIVES: We aimed to determine the effect of exercise training on plasma levels of brain-derived neurotrophic factor (BDNF), and serum insulin-like growth factor-1 (IGF-1) as well as cAMP response element-binding (CREB) activation in peripheral blood mononuclear cells (PBMCs) in adolescents. METHODS: Nine trained and seven sedentary male adolescents, matched in age (14.0+/-2.2 years), were recruited for the study. Trained boys performed higher physical activity levels (expressed both as total energy expenditure and as physical activity energy expenditure) and showed significant bradycardia when compared with sedentary ones. RESULTS: We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones. However, no effect of training was found in the activation of CREB in PBMCs. CONCLUSIONS: We demonstrated the increase of neuroplasticity-related proteins due to exercise training in adolescents. Our results emphasize the significance and impact of exercise in this developmental period. FAU - Pareja-Galeano, H AU - Pareja-Galeano H AD - Department of Physiology, Faculty of Medicine and Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, University of Valencia, Av. Blasco Ibanez 15, Valencia, Spain. helios.pareja@uv.es. FAU - Brioche, T AU - Brioche T FAU - Sanchis-Gomar, F AU - Sanchis-Gomar F FAU - Montal, A AU - Montal A FAU - Jovani, C AU - Jovani C FAU - Martinez-Costa, C AU - Martinez-Costa C FAU - Gomez-Cabrera, M C AU - Gomez-Cabrera MC FAU - Vina, J AU - Vina J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Greece TA - J Musculoskelet Neuronal Interact JT - Journal of musculoskeletal & neuronal interactions JID - 101084496 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (CREB1 protein, human) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adolescent MH - Athletes MH - Brain-Derived Neurotrophic Factor/*blood MH - Cyclic AMP Response Element-Binding Protein/*blood MH - Exercise/*physiology MH - Humans MH - Insulin-Like Growth Factor I/*analysis MH - Leukocytes, Mononuclear/chemistry/metabolism MH - Male MH - Neuronal Plasticity/physiology MH - Physical Fitness/*physiology EDAT- 2013/08/31 06:00 MHDA- 2014/03/22 06:00 CRDT- 2013/08/31 06:00 PHST- 2013/08/31 06:00 [entrez] PHST- 2013/08/31 06:00 [pubmed] PHST- 2014/03/22 06:00 [medline] PST - ppublish SO - J Musculoskelet Neuronal Interact. 2013 Sep;13(3):368-71.