PMID- 23990472
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20211203
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 288
IP  - 41
DP  - 2013 Oct 11
TI  - Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in 
      neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of 
      the E3 ligase Mylip/Idol.
PG  - 29613-20
LID - 10.1074/jbc.M113.500967 [doi]
AB  - BDNF positively influences various aspects of neuronal migration, maturation, and 
      survival in the developing brain. Reelin in turn mediates inhibitory signals to 
      migrating neuroblasts, which is crucial for brain development. The interplay 
      between BDNF and Reelin signaling in neurodevelopment is not fully understood. We 
      show here that BDNF increased the levels of the Reelin receptor (VLDL receptor 
      (VLDLR)) in hippocampal neurons by increasing gene expression. In contrast, 
      Reelin decreased VLDLRs, which was accompanied by an increase in the levels of 
      the E3 ligase Mylip/Idol in neurons. Down-regulation of Mylip/Idol using shRNAs 
      abrogated the decrease in VLDLRs induced by Reelin. These results show that 
      VLDLRs are tightly regulated in hippocampal neurons by both transcriptional and 
      post-transcriptional mechanisms. The regulation of VLDLR by BDNF and Reelin may 
      affect the migration of neurons and contribute to neurodevelopmental disorders in 
      the nervous system.
FAU - Do, Hai Thi
AU  - Do HT
AD  - From the Institute of Biomedicine/Biochemistry and Developmental Biology, 
      University of Helsinki and.
FAU - Bruelle, Celine
AU  - Bruelle C
FAU - Tselykh, Timofey
AU  - Tselykh T
FAU - Jalonen, Pilvi
AU  - Jalonen P
FAU - Korhonen, Laura
AU  - Korhonen L
FAU - Lindholm, Dan
AU  - Lindholm D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130829
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, LDL)
RN  - 0 (Reelin Protein)
RN  - 0 (Reln protein, rat)
RN  - 0 (VLDL receptor)
RN  - EC 2.3.2.27 (Mylip protein, rat)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Adhesion Molecules, Neuronal/*pharmacology
MH  - Cells, Cultured
MH  - Down-Regulation/drug effects
MH  - Extracellular Matrix Proteins/*pharmacology
MH  - Gene Expression/drug effects
MH  - Hippocampus/cytology/embryology
MH  - Immunoblotting
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neurons/cytology/*drug effects/metabolism
MH  - RNA Interference
MH  - Rats, Wistar
MH  - Receptors, LDL/genetics/*metabolism
MH  - Reelin Protein
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serine Endopeptidases/*pharmacology
MH  - Ubiquitin-Protein Ligases/genetics/*metabolism
MH  - Ubiquitination/drug effects
PMC - PMC3795259
OTO - NOTNLM
OT  - Brain-derived Neurotrophic Factor (BDNF)
OT  - Neurodevelopment
OT  - Neurons
OT  - Receptor Regulation
OT  - Ubiquitin Ligase
EDAT- 2013/08/31 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/10/11
CRDT- 2013/08/31 06:00
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/10/11 00:00 [pmc-release]
AID - S0021-9258(20)48780-0 [pii]
AID - M113.500967 [pii]
AID - 10.1074/jbc.M113.500967 [doi]
PST - ppublish
SO  - J Biol Chem. 2013 Oct 11;288(41):29613-20. doi: 10.1074/jbc.M113.500967. Epub 
      2013 Aug 29.