PMID- 23990980
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 8
DP  - 2013
TI  - Risk factors for acute endophthalmitis following cataract surgery: a systematic 
      review and meta-analysis.
PG  - e71731
LID - 10.1371/journal.pone.0071731 [doi]
LID - e71731
AB  - BACKGROUND: Acute endophthalmitis is one of the most serious complications of 
      cataract surgery and often results in severe visual impairment. Several risk 
      factors for acute postoperative endophthalmitis (POE) following cataract surgery 
      have been reported but the level of evidence and strength of association is 
      varied. The purpose of this study was to critically appraise published reports on 
      and to summarize clinical risk factors associated with acute POE which could be 
      easily assessed by ophthalmologists for the introduction and implementation of 
      preventive measure. METHODS: A systematic review and meta-analysis of 
      observational studies was performed. Six databases were searched with no limits 
      on the year or language of publication. Study-specific odds ratios (Ors) or 
      relative risk (RR) of each risk factor were pooled using a random effect model. 
      RESULTS: A total of 6 686 169 participants with 8 963 endophthalmitis in 42 
      studies were analyzed. Of the nine risk factors identified in our systematic 
      review and meta-analysis, extra- or intracapsular cataract extraction, a clear 
      corneal incision, without intracameral cefazolin (1 mg in 0.1 ml solution), 
      without intracameral cefuroxime (1 mg in 0.1 ml solution), post capsular rupture, 
      silicone intraocular lenses and intraoperative complications were found strongly 
      associated with acute endophthalmitis. Other significant factors with a lower 
      strength of association (risk estimates generally 1.5 or less) were male gender 
      and old age (85 years and older). CONCLUSIONS: Our study provides summary data on 
      the risk factors for acute POE. Identifying patients at high risk of this 
      sight-threatening eye disease is important from both the public health and 
      clinical perspectives as this would facilitate detection of disease before the 
      onset of irreversible visual loss enabling earlier intervention.
FAU - Cao, He
AU  - Cao H
AD  - Injury Prevention Research Center, Medical College of Shantou University Shantou, 
      Guangdong Province, People's Republic of China ; Department of Ophthalmology, 
      C-MER(Shenzhen)Dennis Lam Eye Hospital, Shenzhen, Guangdong Province, People's 
      Republic of China.
FAU - Zhang, Lu
AU  - Zhang L
FAU - Li, Liping
AU  - Li L
FAU - Lo, Singkai
AU  - Lo S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20130826
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acute Disease
MH  - Cataract Extraction/*adverse effects
MH  - Endophthalmitis/*etiology
MH  - Humans
MH  - Observational Studies as Topic
MH  - Odds Ratio
MH  - Postoperative Complications/diagnosis/*etiology/prevention & control
MH  - Risk Factors
PMC - PMC3753305
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/08/31 06:00
MHDA- 2014/04/22 06:00
PMCR- 2013/08/26
CRDT- 2013/08/31 06:00
PHST- 2013/03/16 00:00 [received]
PHST- 2013/07/01 00:00 [accepted]
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
PHST- 2013/08/26 00:00 [pmc-release]
AID - PONE-D-13-11270 [pii]
AID - 10.1371/journal.pone.0071731 [doi]
PST - epublish
SO  - PLoS One. 2013 Aug 26;8(8):e71731. doi: 10.1371/journal.pone.0071731. eCollection 
      2013.