PMID- 23991297
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130830
LR  - 20211021
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 5
IP  - 4
DP  - 2013 Aug
TI  - Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary 
      disease? A meta-analysis.
PG  - 422-9
LID - 10.3978/j.issn.2072-1439.2013.08.26 [doi]
AB  - INTRODUCTION: Although several large studies showed roflumilast (Rof) has 
      demonstrated efficacy in patients with chronic obstructive pulmonary disease 
      (COPD), the efficacy of Rof in dyspnea remains unclear. We therefore undertook a 
      meta-analysis to assess the efficacy of Rof in dyspnea for COPD patients. 
      METHODS: A computerized search through electronic databases was performed to 
      obtain randomized controlled trials (RCTs). Dyspnea was assessed by the 
      transition dyspnea index (TDI) and the UCSD Shortness of Breath Questionnaire 
      (SOBQ). The quality of the included studies was assessed by the Jadad score. 
      Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were 
      calculated and heterogeneity was assessed with the I(2) test. The effect sizes 
      were compared with the minimum clinically important difference (MCID). RESULTS: 
      Four RCTs involving 4,767 patients with forced expiratory volume in one second 
      (FEV1) <80% predicted met the inclusion criteria. The Jadad score of each study 
      was 5 scores. Rof statistically improved the TDI focal score (WMD =0.30 units; 
      95% CI: 0.14-0.46), but failed to decrease the SOBQ (WMD =-1.10 units; 95% CI: 
      -4.24 to 2.04). The overall effect sizes were lower than the MCID of the TDI and 
      the SOBQ, respectively. CONCLUSIONS: Sufficient evidence to support Rof relieving 
      dyspnea in COPD patients is currently lacking. Further studies are needed to 
      investigate the effects of Rof in dyspnea, especially for COPD patients with a 
      different phenotype.
FAU - Pan, Lei
AU  - Pan L
AD  - Department of Respiratory and critical care medicine, Affiliated Hospital of 
      Binzhou Medical University, Binzhou 256603, China;
FAU - Guo, Yong-Zhong
AU  - Guo YZ
FAU - Zhang, Bo
AU  - Zhang B
FAU - Yan, Jun-Hong
AU  - Yan JH
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC3755693
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease (COPD)
OT  - dyspnea
OT  - meta-analysis
OT  - roflumilast (Rof)
EDAT- 2013/08/31 06:00
MHDA- 2013/08/31 06:01
PMCR- 2013/08/01
CRDT- 2013/08/31 06:00
PHST- 2013/05/25 00:00 [received]
PHST- 2013/08/13 00:00 [accepted]
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2013/08/31 06:01 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - jtd-05-04-422 [pii]
AID - 10.3978/j.issn.2072-1439.2013.08.26 [doi]
PST - ppublish
SO  - J Thorac Dis. 2013 Aug;5(4):422-9. doi: 10.3978/j.issn.2072-1439.2013.08.26.