PMID- 23991405
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130830
LR  - 20220409
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 37
IP  - 4
DP  - 2013 Aug
TI  - Association of Estrogen Receptor alpha Genes PvuII and XbaI Polymorphisms with Type 2 
      Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran.
PG  - 270-7
LID - 10.4093/dmj.2013.37.4.270 [doi]
AB  - BACKGROUND: Estrogen plays a fundamental role in the pathogenesis of type 2 
      diabetes mellitus (T2DM). Very few studies have shown the association between 
      estrogen receptor alpha (ERalpha), PvuII and XbaI gene polymorphisms with T2DM in both 
      men and women. We evaluated the hypothesis that PvuII and XbaI polymorphisms of 
      ERalpha gene may be associated with T2DM in adult. METHODS: From spring of 2010 to 
      the fall of 2011, a case-control study was performed at clinical centers of 
      Jahrom University of Medical Sciences. We included 174 patients with T2DM 
      including men and women and 174 age, sex, and body mass index frequency-matched 
      health controls. We analyzed the PvuII and XbaI polymorphisms of ERalpha by using the 
      polymerase chain reaction-based restriction fragment length polymorphism method. 
      RESULTS: No significant differences between demographic characteristics of 
      control and patients groups were observed. Allele frequencies of both PvuII and 
      XbaI polymorphisms were significantly different between patients and control 
      subjects (P=0.014 vs. P=0.002, respectively). When the group was separated into 
      women and men, logistic regression analysis of genotype distribution of PvuII (pp 
      vs. Pp+PP) in both sexes revealed that there was no significant association of 
      PvuII genotype with men (odds ratio [OR], 1.67; confidence interval [CI], 0.86 to 
      3.28; P=0.89) and women (OR, 0.96; CI, 0.53 to 1.74; P=0.12). CONCLUSION: PvuII 
      and XbaI polymorphisms in ERalpha are related with T2DM in the inpatient population.
FAU - Mohammadi, Farzaneh
AU  - Mohammadi F
AD  - Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran.
FAU - Pourahmadi, Mohammad
AU  - Pourahmadi M
FAU - Mosalanejad, Mohadeseh
AU  - Mosalanejad M
FAU - Jamali, Houshang
AU  - Jamali H
FAU - Ghobadifar, Mohamed Amin
AU  - Ghobadifar MA
FAU - Erfanian, Saeideh
AU  - Erfanian S
LA  - eng
PT  - Journal Article
DEP - 20130814
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC3753492
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Estrogen receptor alpha
OT  - Genetic
OT  - Humans
OT  - PvuII
OT  - XbaI
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/08/31 06:00
MHDA- 2013/08/31 06:01
PMCR- 2013/08/01
CRDT- 2013/08/31 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/04/03 00:00 [accepted]
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2013/08/31 06:01 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.4093/dmj.2013.37.4.270 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2013 Aug;37(4):270-7. doi: 10.4093/dmj.2013.37.4.270. Epub 2013 
      Aug 14.