PMID- 23991553
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20131121
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 70
IP  - 4
DP  - 2013
TI  - [Evaluation of the interdependence between homocystein and folic acid levels in 
      patients after kidney transplantation during a 2 year observation period].
PG  - 175-9
AB  - Patients on maintenance dialysis have increased heomocystein (Hcy) serum levels. 
      The aim of the study was to evaluate the interdependence between Hcy and folic 
      acid (FA) levels in renal transplant patients (pts) at various time periods 
      during a two year observation period after kidney transplantation (Ktx). PATIENTS 
      AND METHODS: The study included 51 pts (17 F, 34 M) aged 15-62 years (median 
      38.1) after deceased donors Ktx. Before Ktx, 46 pts were treated with maintenance 
      hemodialysis (HD), while 5 by peritoneal dialysis (PD). The mean observation 
      period equaled 21.2 months (6-24 months); while total observation period was 90 
      person/years. Hcy level was measured using high performance liquid chromatography 
      (HPLC). FA level was measured using chemiluminesence method (standard methods) 
      using the Immulite 2000 analyzer. Patients blood was drawn before Ktx and 3, 6, 
      9, 12, 15, 18, 21 and 24 months after procedure. RESULTS: An increased Hcy level 
      (>15 micromol/l) - mean 28.5 +/- 17.8 micromol/l (range from 10.2 micromol/l to 
      116.8 micromol/I) was noted in the blood of 44 pts before Ktx (86.3% of the 
      examined population). In 31 pts after Ktx (60.8% of the examined population), 
      mean Hcy level remained increased above 15 micromol/I (mean Hcy - 19.2 +/- 5.8 
      micromol/I). A negative correlation was found between the levels of Hcy and FA 
      directly before Ktx (R= -0.28, p<0.05). A statistically significant drop of FA 
      level of 72.6% (mean 220.5 +/- 395.1 ng/ml to 60.3 +/- 129.8 ng/ mi) was noted 3 
      months after Ktx in the examined group (p<0.001 in the Wilcoxon test). However, 
      in the following period time after Ktx, FA levels did not differ statistically 
      (ANOVA Friedmana p=NS). Mean concentrations of Hcy after Ktx did not correlate 
      significantly with levels of FA (R = -0.12, p = NS). No significant differences 
      between mean levels of FA after Ktx in pts with normal and increased mean levels 
      of Hcy were found; but one must note that presence of hiperhomocysteinemia (HHcy) 
      was associated with a 42% lower concentration of FA in relation to patients who 
      had Hcy >15 micromol/l (36.4 ng/ml vs. 62.5 ng/ml). CONCLUSIONS: Statistically 
      significant decrease of Hcy concentration was observed after Ktx as compare with 
      values before procedure, however not reached normal values. Significant decrease 
      of FA concentration after Ktx is most likely associated with the discontinuation 
      of FA supplementation, as well as due to the restoration of the erythropoietic 
      line.
FAU - Janda, Katarzyna
AU  - Janda K
AD  - Katedra i Klinika Nefrologii Uniwersytetu Jagielllonskiego Collegium Medicum, 
      Krakow. kasiajanda@op.pl
FAU - Aksamit, Dariusz
AU  - Aksamit D
FAU - Krzanowski, Marcin
AU  - Krzanowski M
FAU - Kuzniewski, Marek
AU  - Kuzniewski M
FAU - Sulowicz, Wladyslaw
AU  - Sulowicz W
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Ocena zaleznosci homocysteinemii i kwasu foliowego u chorych po przeszczepieniu 
      nerki w roznych okresach od momentu wykonania zabiegu w trakcie dwuletniej 
      obserwacji.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Folic Acid/*blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Kidney Failure, Chronic/blood/therapy
MH  - Kidney Transplantation/*physiology
MH  - Male
MH  - Middle Aged
MH  - Peritoneal Dialysis
MH  - Renal Dialysis
MH  - Young Adult
EDAT- 2013/09/03 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
PST - ppublish
SO  - Przegl Lek. 2013;70(4):175-9.