PMID- 23991635
OWN - NLM
STAT- MEDLINE
DCOM- 20140627
LR  - 20220410
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 19
IP  - 12
DP  - 2013 Dec
TI  - Cost-benefit of infection control interventions targeting methicillin-resistant 
      Staphylococcus aureus in hospitals: systematic review.
PG  - E582-93
LID - 10.1111/1469-0691.12280 [doi]
AB  - Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) incur 
      significant costs. We aimed to examine the cost and cost-benefit of infection 
      control interventions against MRSA and to examine factors affecting economic 
      estimates. We performed a systematic review of studies assessing infection 
      control interventions aimed at preventing spread of MRSA in hospitals and 
      reporting intervention costs, savings, cost-benefit or cost-effectiveness. We 
      searched PubMed and references of included studies with no language restrictions 
      up to January 2012. We used the Quality of Health Economic Studies tool to assess 
      study quality. We report cost and savings per month in 2011 US$. We calculated 
      the median save/cost ratio and the save-cost difference with interquartile range 
      (IQR) range. We examined the effects of MRSA endemicity, intervention duration 
      and hospital size on results. Thirty-six studies published between 1987 and 2011 
      fulfilled inclusion criteria. Fifteen of the 18 studies reporting both costs and 
      savings reported a save/cost ratio >1. The median save/cost ratio across all 18 
      studies was 7.16 (IQR 1.37-16). The median cost across all studies reporting 
      intervention costs (n = 31) was 8648 (IQR 2025-19 170) US$ per month; median 
      savings were 38 751 (IQR 14 206-75 842) US$ per month (23 studies). Higher 
      save/cost ratios were observed in the intermediate to high endemicity setting 
      compared with the low endemicity setting, in hospitals with <500-beds and with 
      interventions of >6 months. Infection control intervention to reduce spread of 
      MRSA in acute-care hospitals showed a favourable cost/benefit ratio. This was 
      true also for high MRSA endemicity settings. Unresolved economic issues include 
      rapid screening using molecular techniques and universal versus targeted 
      screening.
CI  - (c) 2013 The Authors Clinical Microbiology and Infection (c) 2013 European Society of 
      Clinical Microbiology and Infectious Diseases.
FAU - Farbman, L
AU  - Farbman L
AD  - Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah-Tikva, Israel; Leon 
      Recanati Faculty of Management and Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel-Aviv, Israel.
FAU - Avni, T
AU  - Avni T
FAU - Rubinovitch, B
AU  - Rubinovitch B
FAU - Leibovici, L
AU  - Leibovici L
FAU - Paul, M
AU  - Paul M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20130828
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
SB  - IM
MH  - Cost Savings
MH  - Cost-Benefit Analysis
MH  - Cross Infection/epidemiology/microbiology/*prevention & control/transmission
MH  - Hospitals
MH  - Humans
MH  - Infection Control/*economics/methods
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Staphylococcal Infections/epidemiology/microbiology/*prevention & 
      control/transmission
OTO - NOTNLM
OT  - Contact isolation
OT  - MRSA
OT  - cost-benefit
OT  - decolonization
OT  - economic analysis
OT  - screening
EDAT- 2013/09/03 06:00
MHDA- 2014/06/28 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/02/12 00:00 [received]
PHST- 2013/05/12 00:00 [revised]
PHST- 2013/05/23 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/06/28 06:00 [medline]
AID - S1198-743X(14)63098-6 [pii]
AID - 10.1111/1469-0691.12280 [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2013 Dec;19(12):E582-93. doi: 10.1111/1469-0691.12280. 
      Epub 2013 Aug 28.