PMID- 23991682
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20130930
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 68
IP  - 9
DP  - 2013 Sep
TI  - The history of mast cell and basophil research - some lessons learnt from the 
      last century.
PG  - 1093-101
LID - 10.1111/all.12197 [doi]
AB  - This year (2013) marks the 50th anniversary of death of Otto Carl Willy Prausnitz 
      (1876-1963) and Heinz Kustner (1897-1963). The two physicians, when working at 
      the Hygiene Institute at the University of Breslau, Germany (Prausnitz was the 
      Head of the Institute), described in 1921 what is still called today the 
      Prausnitz-Kustner or PK reaction showing that allergy could be transferred from 
      the allergic person by transferring serum to a healthy person. Their discovery 
      ended the belief that an anaphylactic/allergic reaction was caused by poisons, 
      but to the contrary showed that the presence of the hypersensitivity factor could 
      be transferred to other people. We know now that this factor is immunoglobulin E 
      (IgE), sensitizing mast cells and basophils to respond to an allergic stimulus. 
      We take this occasion to retrace some of the important discoveries and lessons 
      learnt from the last century relating to the function of these two cell types as 
      effectors of the IgE system and the mediators they produce.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Blank, U
AU  - Blank U
AD  - INSERM UMRS 699, Paris, France; Laboratoire d'excellence INFLAMEX, Sorbonne Paris 
      Cite, Universite Paris Diderot, Paris, France.
FAU - Falcone, F H
AU  - Falcone FH
FAU - Nilsson, G
AU  - Nilsson G
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20130830
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/immunology
MH  - Animals
MH  - Basophils/cytology/*immunology/metabolism
MH  - History, 20th Century
MH  - Humans
MH  - Immunity, Innate
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/cytology/*immunology/metabolism
MH  - Parasitic Diseases/immunology
MH  - *Research/history
OTO - NOTNLM
OT  - allergy
OT  - anaphylaxis
OT  - basophils
OT  - history
OT  - mast cells
EDAT- 2013/09/03 06:00
MHDA- 2014/05/09 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/05/02 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - 10.1111/all.12197 [doi]
PST - ppublish
SO  - Allergy. 2013 Sep;68(9):1093-101. doi: 10.1111/all.12197. Epub 2013 Aug 30.