PMID- 23992681
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20201206
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 151
IP  - 2
DP  - 2013 Nov
TI  - BDNF promoter methylation and suicidal behavior in depressive patients.
PG  - 679-685
LID - S0165-0327(13)00586-7 [pii]
LID - 10.1016/j.jad.2013.08.001 [doi]
AB  - INTRODUCTION: Suicide is a major health problem, and depression is a major 
      psychiatric cause of suicide. Suicide is influenced by the multifactorial 
      interaction of many risk factors. Therefore, epigenetic research may lead to 
      understandings that are applicable to suicide. This study investigated whether 
      epigenetic changes are associated with suicidal behavior and evaluated the 
      treatment outcome of suicidal ideation in depressive patients. METHODS: In 108 
      patients with major depression, the promoter methylation of the gene encoding 
      brain-derived neurotrophic factor (BDNF) was measured. Sociodemographic and 
      clinical characteristics including a history of previous depressive episodes, age 
      at onset, duration of illnesses, family history of depression, and number of 
      stressful life events as well as subjective perception of stress and assessment 
      scales for depression (HAMD), anxiety (HAMA), function (SOFAS), disability 
      (WHODAS-12), and quality of life (WHOQOL-BREF) were evaluated at baseline. 
      Suicidal behavior was ascertained using a semistructured clinical interview with 
      questions about severity and intent. Beck Scale for Suicide Ideation (BSS) was 
      administered during 12 weeks of treatment with antidepressants. RESULTS: A higher 
      BDNF promoter methylation status was significantly associated with a previous 
      suicidal attempt history, suicidal ideation during treatment, and suicidal 
      ideation at last evaluation as well as with higher BSS scores and poor treatment 
      outcomes for suicidal ideation. LIMITATIONS: Methylation status was investigated 
      with limited area of the BDNF gene and sample size was relatively small. 
      CONCLUSIONS: BDNF methylation status could be a proxy marker for previous 
      suicidal attempts and a clinical biomarker for poor treatment outcomes of 
      suicidal ideation in depression.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea. Electronic address: jmkim@chonnam.ac.kr.
FAU - Lee, Ju-Yeon
AU  - Lee JY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Seon-Young
AU  - Kim SY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Bae, Kyung-Yeol
AU  - Bae KY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Hye-Ran
AU  - Kim HR
AD  - Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National 
      University Medical School, Gwangju, Republic of Korea.
FAU - Shin, Myung-Geun
AU  - Shin MG
AD  - Department of Laboratory Medicine, Chonnam National University Medical School, 
      Gwangju, Republic of Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130813
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Depressive Disorder, Major/drug therapy/epidemiology/*genetics/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Methylation
MH  - Middle Aged
MH  - Promoter Regions, Genetic/*physiology
MH  - Risk Factors
MH  - *Suicidal Ideation
MH  - *Suicide, Attempted
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF
OT  - DNA methylation
OT  - Epigenetics
OT  - Suicidal behavior
OT  - Treatment
EDAT- 2013/09/03 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/08/01 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - S0165-0327(13)00586-7 [pii]
AID - 10.1016/j.jad.2013.08.001 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Nov;151(2):679-685. doi: 10.1016/j.jad.2013.08.001. Epub 
      2013 Aug 13.