PMID- 23993283
OWN - NLM
STAT- MEDLINE
DCOM- 20141015
LR  - 20140207
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 51
DP  - 2014 Feb
TI  - Cognitive and neuroimaging evidence of impaired interaction between self and 
      memory in Alzheimer's disease.
PG  - 11-24
LID - S0010-9452(13)00170-6 [pii]
LID - 10.1016/j.cortex.2013.06.009 [doi]
AB  - In human cognition, self and memory processes strongly interact, as evidenced by 
      the memory advantage for self-referential materials [Self-Reference Effect (SRE) 
      and Self-Reference Recollection Effect (SRRE)]. The current study examined this 
      interaction at the behavioural level and its neural correlates in patients with 
      Alzheimer's disease (AD). Healthy older controls (HC) and AD patients performed 
      trait-adjectives judgements either for self-relevance or for other-relevance 
      (encoding phase). In a first experiment, the encoding and subsequent yes-no 
      recognition phases were administrated in a Magnetic Resonance Imaging (MRI) 
      scanner. Brain activation as measured by functional MRI (fMRI) was examined 
      during self-relevance judgements and anatomical images were used to search for 
      correlation between the memory advantage for self-related items and grey matter 
      density (GMD). In a second experiment, participants described the retrieval 
      experience that had driven their recognition decisions (familiarity vs 
      recollective experience). The behavioural results revealed that the SRE and SRRE 
      were impaired in AD patients compared to HC participants. Furthermore, verbal 
      reports revealed that the retrieval of self-related information was 
      preferentially associated with the retrieval of contextual details, such as 
      source memory in the HC participants, but less so in the AD patients. Our imaging 
      findings revealed that both groups activated the medial prefrontal cortex (MPFC) 
      at encoding during self-relevance judgements. However, the variable and limited 
      memory advantage for self-related information was associated with GMD in the 
      lateral prefrontal cortex in the AD patients, a region supporting high-order 
      processes linking self and memory. These findings suggest that even if AD 
      patients engage MPFC during self-referential judgements, the retrieval of 
      self-related memories is qualitatively and quantitatively impaired in relation 
      with altered high-order processes in the lateral PFC.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Genon, Sarah
AU  - Genon S
AD  - Cyclotron Research Centre, University of Liege, Belgium. Electronic address: 
      Sarah.Genon@ulg.ac.be.
FAU - Bahri, Mohamed Ali
AU  - Bahri MA
AD  - Cyclotron Research Centre, University of Liege, Belgium.
FAU - Collette, Fabienne
AU  - Collette F
AD  - Cyclotron Research Centre, University of Liege, Belgium.
FAU - Angel, Lucie
AU  - Angel L
AD  - University Francois-Rabelais of Tours, UMR CNRS 7295 CeRCA, Tours, France.
FAU - d'Argembeau, Arnaud
AU  - d'Argembeau A
AD  - Cyclotron Research Centre, University of Liege, Belgium; Department of 
      Psychology, University of Liege, Belgium.
FAU - Clarys, David
AU  - Clarys D
AD  - University of Poitiers, UMR CNRS 7295 CeRCA, Poitiers, France.
FAU - Kalenzaga, Sandrine
AU  - Kalenzaga S
AD  - University of Paris Descartes, Paris, France.
FAU - Salmon, Eric
AU  - Salmon E
AD  - Cyclotron Research Centre, University of Liege, Belgium; Memory Centre, CHU 
      Liege, Belgium.
FAU - Bastin, Christine
AU  - Bastin C
AD  - Cyclotron Research Centre, University of Liege, Belgium. Electronic address: 
      Christine.Bastin@ulg.ac.be.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130702
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
CIN - Cortex. 2014 May;54:213-8. PMID: 24674099
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/physiopathology/*psychology
MH  - Brain Mapping/methods
MH  - Cognition/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory/*physiology
MH  - Middle Aged
MH  - *Neuroimaging
MH  - Neuropsychological Tests
MH  - Self Concept
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Memory
OT  - Recollection
OT  - Self-reference effect
OT  - fMRI
EDAT- 2013/09/03 06:00
MHDA- 2014/10/16 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/06/13 00:00 [revised]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/10/16 06:00 [medline]
AID - S0010-9452(13)00170-6 [pii]
AID - 10.1016/j.cortex.2013.06.009 [doi]
PST - ppublish
SO  - Cortex. 2014 Feb;51:11-24. doi: 10.1016/j.cortex.2013.06.009. Epub 2013 Jul 2.