PMID- 23994476
OWN - NLM
STAT- MEDLINE
DCOM- 20140612
LR  - 20220410
IS  - 2211-1247 (Electronic)
VI  - 4
IP  - 5
DP  - 2013 Sep 12
TI  - Increased mammalian lifespan and a segmental and tissue-specific slowing of aging 
      after genetic reduction of mTOR expression.
PG  - 913-20
LID - S2211-1247(13)00392-6 [pii]
LID - 10.1016/j.celrep.2013.07.030 [doi]
AB  - We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) 
      hypomorphic mouse model. Mice with two hypomorphic (mTOR(Delta/Delta)) alleles are viable 
      but express mTOR at approximately 25% of wild-type levels. These animals 
      demonstrate reduced mTORC1 and mTORC2 activity and exhibit an approximately 20% 
      increase in median survival. While mTOR(Delta/Delta) mice are smaller than wild-type 
      mice, these animals do not demonstrate any alterations in normalized food intake, 
      glucose homeostasis, or metabolic rate. Consistent with their increased lifespan, 
      mTOR(Delta/Delta) mice exhibited a reduction in a number of aging tissue biomarkers. 
      Functional assessment suggested that, as mTOR(Delta/Delta) mice age, they exhibit a 
      marked functional preservation in many, but not all, organ systems. Thus, in a 
      mammalian model, while reducing mTOR expression markedly increases overall 
      lifespan, it affects the age-dependent decline in tissue and organ function in a 
      segmental fashion.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wu, J Julie
AU  - Wu JJ
AD  - Center for Molecular Medicine, National Heart, Lung and Blood Institute, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Liu, Jie
AU  - Liu J
FAU - Chen, Edmund B
AU  - Chen EB
FAU - Wang, Jennifer J
AU  - Wang JJ
FAU - Cao, Liu
AU  - Cao L
FAU - Narayan, Nisha
AU  - Narayan N
FAU - Fergusson, Marie M
AU  - Fergusson MM
FAU - Rovira, Ilsa I
AU  - Rovira II
FAU - Allen, Michele
AU  - Allen M
FAU - Springer, Danielle A
AU  - Springer DA
FAU - Lago, Cory U
AU  - Lago CU
FAU - Zhang, Shuling
AU  - Zhang S
FAU - DuBois, Wendy
AU  - DuBois W
FAU - Ward, Theresa
AU  - Ward T
FAU - deCabo, Rafael
AU  - deCabo R
FAU - Gavrilova, Oksana
AU  - Gavrilova O
FAU - Mock, Beverly
AU  - Mock B
FAU - Finkel, Toren
AU  - Finkel T
LA  - eng
GR  - ZIA HL005012-16/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20130829
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Female
MH  - Glucose/metabolism
MH  - Homeostasis
MH  - Longevity/*physiology
MH  - Male
MH  - Mammals
MH  - Mice
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/biosynthesis/*deficiency/*genetics
PMC - PMC3784301
MID - NIHMS511713
EDAT- 2013/09/03 06:00
MHDA- 2014/06/13 06:00
PMCR- 2013/09/26
CRDT- 2013/09/03 06:00
PHST- 2013/02/14 00:00 [received]
PHST- 2013/07/11 00:00 [revised]
PHST- 2013/07/24 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/06/13 06:00 [medline]
PHST- 2013/09/26 00:00 [pmc-release]
AID - S2211-1247(13)00392-6 [pii]
AID - 10.1016/j.celrep.2013.07.030 [doi]
PST - ppublish
SO  - Cell Rep. 2013 Sep 12;4(5):913-20. doi: 10.1016/j.celrep.2013.07.030. Epub 2013 
      Aug 29.