PMID- 23994586
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 12
DP  - 2013 Dec
TI  - The association between human leukocyte antigen (HLA)-G polymorphisms and human 
      papillomavirus (HPV) infection in Inuit women of northern Quebec.
PG  - 1610-5
LID - S0198-8859(13)00504-1 [pii]
LID - 10.1016/j.humimm.2013.08.279 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA)-G molecules act as negative 
      regulators of the immune response. We analyzed the associations between HLA G 
      polymorphisms and human papillomavirus (HPV) infection and squamous 
      intraepithelial lesions (SIL) in Inuit women from Nunavik, northern Quebec. 
      METHODS: Cervical specimens from a cohort study of 548 Inuit women were tested 
      for HPV DNA. HPV genotypes were classified according to tissue-tropism groupings 
      of alpha-papillomavirus species: alpha group 1 includes low risk (LR) cervical 
      species, group 2 includes high risk (HR) cervical species, and group 3 includes 
      LR vaginal species. HLA-G alleles were typed using direct DNA sequencing. 
      RESULTS: HLA-G( *)01:01:01 was associated with an increased risk of period 
      prevalent alpha groups 1 (OR = 2.23, 95% CI:1.08-4.59) and 3 (OR = 1.70, 95% 
      CI:1.09-2.65). The homozygous HLA-G( *)01:04:01 genotype was associated with a 
      decreased risk of alpha group 3 infection period prevalence (OR = 1.69 95% CI = 
      1.07-2.67). No HLA-G alleles were significantly associated with HPV persistence. 
      HLA-G( *)01:01:02, G( *)01:04:01 and G( *)01:06 were associated with high grade 
      (HG)SIL, but the association did not reach statistical significance. CONCLUSIONS: 
      These results suggest that HLA-G polymorphisms play a role in the natural history 
      of HPV infection, likely at the stage of host immune recognition. HLA-G 
      polymorphisms interacted differently with the three alpha papillomavirus groups.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Metcalfe, Stephanie
AU  - Metcalfe S
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, 1020 Pine Ave. West Montreal, QC H3A 1A2, Canada.
FAU - Roger, Michel
AU  - Roger M
FAU - Faucher, Marie-Claude
AU  - Faucher MC
FAU - Coutlee, Francois
AU  - Coutlee F
FAU - Franco, Eduardo L
AU  - Franco EL
FAU - Brassard, Paul
AU  - Brassard P
LA  - eng
PT  - Journal Article
DEP - 20130829
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Alleles
MH  - Alphapapillomavirus/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-G Antigens/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Inuit/*genetics
MH  - Odds Ratio
MH  - Papillomavirus Infections/*genetics/immunology
MH  - *Polymorphism, Genetic
MH  - Quebec
EDAT- 2013/09/03 06:00
MHDA- 2014/07/19 06:00
CRDT- 2013/09/03 06:00
PHST- 2012/12/19 00:00 [received]
PHST- 2013/08/12 00:00 [revised]
PHST- 2013/08/20 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - S0198-8859(13)00504-1 [pii]
AID - 10.1016/j.humimm.2013.08.279 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Dec;74(12):1610-5. doi: 10.1016/j.humimm.2013.08.279. Epub 2013 
      Aug 29.