PMID- 23995205
OWN - NLM
STAT- MEDLINE
DCOM- 20140225
LR  - 20130902
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 25 Suppl 2
DP  - 2013 Sep
TI  - The role of brain-derived neurotrophic factor in the pathophysiology of suicidal 
      behavior.
PG  - S341-4
AB  - Suicidal behaviour is a major public health concern. It is known that the 
      pathogenesis of suicidal behaviour involves altered neural plasticity, resulting 
      in the aberrant stress response of the central nervous system to environmental 
      factors. Indeed, altered brain structure and function was found in suicide 
      victims. Neurotrophins are growth factors that are involved in the regulation of 
      structural, synaptic, and morphological plasticity and in the modulation of the 
      strength and number of synaptic connections and neurotransmission. Brain-derived 
      neurotrophic factor (BDNF) the most studied and the most widely distributed among 
      neurotrophins binds to a tropomyosin-related kinase B (TrkB) receptor and to a 
      pan75 neurotrophins receptor. It has been reported that BDNF production is 
      decreased in all patients with suicidal behaviour and in all suicide victims 
      regardless of a psychiatric diagnosis. It was also found that the mRNA and 
      protein level of BDNF was significantly lower in both the prefrontal cortex and 
      the hippocampus of suicide subjects. Different mechanisms could be involved in 
      the regulation of BDNF gene expression, among which epigenetic mechanisms seem to 
      play a key role. However, also for a functional polymorphism (rs6265) Val66Metit 
      has been shown that the Met allele is associated with the reduced BDNF activity. 
      Further, a recent meta-analysis including 12 studies showed a trend for the 
      Met-carrying genotypes and Met allele conferring risk for suicide. Among included 
      studies, our study with the largest sample size, indicated that the combined 
      Met/Met and Met/Val genotypes of the BDNF Val66Met variant could be the risk 
      factor for violent suicide in female subjects and for suicide in victims exposed 
      to childhood trauma. In accordance with previous reports, our findings 
      demonstrate that aberrant regulation of BDNF synthesis is associated with 
      suicidal behaviour.
FAU - Paska, Alja Videtic
AU  - Paska AV
AD  - University of Ljubljana, Medical Faculty, Department of Psychiatry, Zaloska 29, 
      SI-1000 Ljubljana, Slovenia, peter.pregelj@psih-klinika.si.
FAU - Zupanc, Tomaz
AU  - Zupanc T
FAU - Pregelj, Peter
AU  - Pregelj P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Suicide/statistics & numerical data
EDAT- 2013/10/23 06:00
MHDA- 2014/02/26 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/02/26 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2013 Sep;25 Suppl 2:S341-4.