PMID- 23995234
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20230513
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 14
IP  - 10
DP  - 2013 Oct
TI  - IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing 
      expression of the immunoregulatory molecule CD39.
PG  - 1054-63
LID - 10.1038/ni.2695 [doi]
AB  - Dendritic cells (DCs) control the balance between effector T cells and regulatory 
      T cells in vivo. Hence, the study of DCs might identify mechanisms of disease 
      pathogenesis and guide new therapeutic approaches for disorders mediated by the 
      immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs 
      limited the generation of effector cells of the TH1 and TH17 subsets of helper T 
      cells and the development of experimental autoimmune encephalomyelitis (EAE). The 
      effects of IL-27 were mediated at least in part through induction of the 
      immunoregulatory molecule CD39 in DCs. IL-27-induced CD39 decreased the 
      extracellular concentration of ATP and downregulated nucleotide-dependent 
      activation of the NLRP3 inflammasome. Finally, therapeutic vaccination with 
      IL-27-conditioned DCs suppressed established relapsing-remitting EAE. Thus, IL-27 
      signaling in DCs limited pathogenic T cell responses and the development of 
      autoimmunity.
FAU - Mascanfroni, Ivan D
AU  - Mascanfroni ID
AD  - 1] Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical 
      School, Boston, Massachusetts, USA. [2].
FAU - Yeste, Ada
AU  - Yeste A
FAU - Vieira, Silvio M
AU  - Vieira SM
FAU - Burns, Evan J
AU  - Burns EJ
FAU - Patel, Bonny
AU  - Patel B
FAU - Sloma, Ido
AU  - Sloma I
FAU - Wu, Yan
AU  - Wu Y
FAU - Mayo, Lior
AU  - Mayo L
FAU - Ben-Hamo, Rotem
AU  - Ben-Hamo R
FAU - Efroni, Sol
AU  - Efroni S
FAU - Kuchroo, Vijay K
AU  - Kuchroo VK
FAU - Robson, Simon C
AU  - Robson SC
FAU - Quintana, Francisco J
AU  - Quintana FJ
LA  - eng
SI  - GEO/GSE49328
GR  - R21 CA164970/CA/NCI NIH HHS/United States
GR  - K99 AI075285/AI/NIAID NIH HHS/United States
GR  - R56 AI093903/AI/NIAID NIH HHS/United States
GR  - R01 AI093903/AI/NIAID NIH HHS/United States
GR  - AI075285/AI/NIAID NIH HHS/United States
GR  - R00 AI075285/AI/NIAID NIH HHS/United States
GR  - AI093903/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130901
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antibodies)
RN  - 0 (Antigens, CD)
RN  - 0 (Autoantibodies)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Il27ra protein, mouse)
RN  - 0 (Interleukin-17)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Interleukin)
RN  - EC 3.6.1.5 (Apyrase)
RN  - EC 3.6.1.5 (CD39 antigen)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Antigen Presentation/drug effects/immunology
MH  - Antigens, CD/*genetics/metabolism
MH  - Apyrase/*genetics/metabolism
MH  - Autoantibodies/immunology
MH  - *Autoimmunity/drug effects
MH  - Carrier Proteins/metabolism
MH  - Cell Differentiation/genetics/immunology
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*drug effects/*immunology/metabolism
MH  - Encephalomyelitis, Autoimmune, Experimental/genetics/immunology
MH  - Gene Expression
MH  - Gene Expression Regulation/drug effects
MH  - Immune Tolerance/immunology
MH  - Interleukin-17/*pharmacology
MH  - Mice
MH  - Mice, Knockout
MH  - Myelin Sheath/immunology
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Receptors, Cytokine/genetics/metabolism
MH  - Receptors, Interleukin
MH  - Signal Transduction
MH  - T-Lymphocyte Subsets/cytology/*drug effects/*immunology
MH  - Transcription, Genetic/drug effects
PMC - PMC3964005
MID - NIHMS556156
COIS- Competing financial interests The authors declare no competing financial 
      interests.
EDAT- 2013/09/03 06:00
MHDA- 2013/11/16 06:00
PMCR- 2014/10/01
CRDT- 2013/09/03 06:00
PHST- 2013/03/18 00:00 [received]
PHST- 2013/07/19 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - ni.2695 [pii]
AID - 10.1038/ni.2695 [doi]
PST - ppublish
SO  - Nat Immunol. 2013 Oct;14(10):1054-63. doi: 10.1038/ni.2695. Epub 2013 Sep 1.