PMID- 23996382 OWN - NLM STAT- MEDLINE DCOM- 20140623 LR - 20230921 IS - 1098-1063 (Electronic) IS - 1050-9631 (Print) IS - 1050-9631 (Linking) VI - 23 IP - 11 DP - 2013 Nov TI - Use it and boost it with physical and mental activity. PG - 1125-35 LID - 10.1002/hipo.22197 [doi] AB - One of the now classic tenets of neuroscience is that the brain retains a substantial amount of structural and functional plasticity throughout adulthood and old age. Enriching experiences that stimulate physical and mental activity produce robust changes in subsequent behaviors, including learning and memory, that tap a wide range of neural systems. In this article, we review evidence for cognitive priming with physical and mental exercise through a memory systems lens and present brain-derived neurotrophic factor (BDNF) signaling as one candidate neural mechanism for experience-dependent modulation of learning and memory. We highlight our recent findings showing that priming with voluntary exercise or with spontaneous alternation, a working memory task, enhances new learning of hippocampus-sensitive place, or striatum-sensitive response tasks. Blocking BDNF signaling with infusions of a BDNF receptor inhibitor into hippocampus or striatum just before training on place or response tasks, respectively, abrogated the benefits of priming regardless of the type of priming experience. These results suggest that enhanced BDNF signaling during learning may itself produce the cognitive benefits afforded by prior physical or mental activity. CI - Copyright (c) 2013 Wiley Periodicals, Inc. FAU - Korol, Donna L AU - Korol DL AD - Department of Biology, Syracuse University, Syracuse, New York. FAU - Gold, Paul E AU - Gold PE FAU - Scavuzzo, Claire J AU - Scavuzzo CJ LA - eng GR - P50 AT006268/AT/NCCIH NIH HHS/United States GR - P50AT006268/AT/NCCIH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review PL - United States TA - Hippocampus JT - Hippocampus JID - 9108167 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Aging/*physiology/*psychology MH - Animals MH - Brain-Derived Neurotrophic Factor/physiology MH - Corpus Striatum/physiology MH - Hippocampus/physiology MH - Humans MH - Learning/*physiology MH - Maze Learning/physiology MH - Memory/*physiology MH - Motor Activity/*physiology MH - Neuronal Plasticity/physiology MH - Signal Transduction MH - Systems Biology PMC - PMC8734651 MID - NIHMS1766684 OTO - NOTNLM OT - BDNF OT - learning strategy OT - memory systems OT - plasticity OT - voluntary exercise EDAT- 2013/09/03 06:00 MHDA- 2014/06/24 06:00 PMCR- 2022/01/06 CRDT- 2013/09/03 06:00 PHST- 2013/08/26 00:00 [received] PHST- 2013/08/26 00:00 [accepted] PHST- 2013/09/03 06:00 [entrez] PHST- 2013/09/03 06:00 [pubmed] PHST- 2014/06/24 06:00 [medline] PHST- 2022/01/06 00:00 [pmc-release] AID - 10.1002/hipo.22197 [doi] PST - ppublish SO - Hippocampus. 2013 Nov;23(11):1125-35. doi: 10.1002/hipo.22197.