PMID- 23996394
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20181202
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 27
IP  - 19
DP  - 2013 Oct 15
TI  - Drugs as matrix to detect their own drug delivery system of PEG-b-PCL block 
      copolymers in matrix-assisted laser desorption/ionization time-of-flight mass 
      spectrometry.
PG  - 2201-12
LID - 10.1002/rcm.6663 [doi]
AB  - RATIONALE: The fate of drug delivery systems (DDSs) in vivo is a widely discussed 
      question. Matrix-assisted laser desorption/ionization time-of-flight mass 
      spectrometry (MALDI-TOF MS) is an important tool to localize proteins and small 
      compounds in many different tissues. This basic study was performed as an aid to 
      obtain spatial information on DDSs in the future. METHODS: LDI and MALDI-TOF MS 
      was used to investigate five drug molecules, i.e. madurahydroxylactone (MHL), 
      tetrakis(4-hydroxyphenyl)porphyrin (THP), chartreusin (Chart), amphotericin B 
      (AmB) and retinoic acid (RA). The drug molecules were analyzed in terms of their 
      efficiency to act as matrix for different homopolymers and the block copolymer 
      poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-b-PCL). The block copolymer 
      was further utilized as a DDS to encapsulate the drug molecules previously 
      investigated as matrices. The obtained DDSs were investigated by MALDI. RESULTS: 
      The spectra obtained with the drugs Chart, MHL, THP and AmB did not reach the 
      quality of the standard matrix RA. Nonetheless, they showed surprisingly good 
      results as matrices for different homopolymers and the block copolymer. However, 
      only the DDSs containing THP as the drug provided spectra where the drug and the 
      block copolymer were detected. CONCLUSIONS: These results form the foundation for 
      obtaining mass-related information about the localization of DDSs and drugs in 
      tissues.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Knop, Katrin
AU  - Knop K
AD  - Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller 
      University Jena, Jena, Germany.
FAU - Stumpf, Steffi
AU  - Stumpf S
FAU - Schubert, Ulrich S
AU  - Schubert US
LA  - eng
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Capsules)
RN  - 0 (Lactones)
RN  - 0 (Micelles)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (poly(ethylene glycol)-block-poly(epsilon-caprolactone))
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Capsules/chemistry
MH  - Drug Delivery Systems/*instrumentation
MH  - Lactones/*chemistry
MH  - Micelles
MH  - Models, Chemical
MH  - Pharmaceutical Preparations/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
EDAT- 2013/09/03 06:00
MHDA- 2014/02/25 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/01/23 00:00 [received]
PHST- 2013/06/10 00:00 [revised]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - 10.1002/rcm.6663 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2013 Oct 15;27(19):2201-12. doi: 10.1002/rcm.6663.