PMID- 23996716
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20211119
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 12
IP  - 4
DP  - 2013 Aug 28
TI  - IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in 
      Pakistani patients.
PG  - 391-6
AB  - Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) 
      synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide 
      polymorphisms in IL-13 are associated with allergic phenotypes in several 
      ethnically diverse populations.This study was performed in 214 atopic patients 
      (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). 
      Genotyping of IL-13 gene polymorphisms was performed using polymerase chain 
      reaction-based restriction fragment length polymorphism method.A statistically 
      significant association of the A-1512C polymorphism in IL13 gene was observed 
      with atopy (p<0.001; chi2=19.0). Upon stratification of the data into asthma and 
      AR association was revealed with both asthma (p=0.01; chi2=8.80) and AR 
      (p<0.001; chi2=24.3) in Pakistani patients. Higher odds ratio (OR 95% CI) was 
      observed for AR 3.42 (2.04-5.76) relative to asthma 2.40 (1.41-4.09) for the C 
      allele compared to controls.In conclusion the study provides the evidence A-1512C 
      polymorphisms in IL-13 is a risk factor for asthma and AR.
FAU - Shazia, Micheal
AU  - Shazia M
AD  - Department of Biosciences, COMSATS Institute of Information Technology, 
      Islamabad-44000, Pakistan and Department of Ophthalmology, Radboud University 
      Nijmegen Medical Centre; Nijmegen, Netherlands. shaziamicheal@gmail.com.
FAU - Kanza, Minhas
AU  - Kanza M
FAU - Mehwish, Ishaque
AU  - Mehwish I
FAU - Irum, Shabbir
AU  - Irum S
FAU - Farida, Ahmed
AU  - Farida A
FAU - Asifa, Ahmed
AU  - Asifa A
LA  - eng
PT  - Journal Article
DEP - 20130828
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (IL13 protein, human)
RN  - 0 (Interleukin-13)
SB  - IM
CIN - Iran J Allergy Asthma Immunol. 2014 Aug;13(4):298-9. PMID: 24659168
MH  - Asthma/etiology/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Interleukin-13/*genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/etiology/*genetics
EDAT- 2013/09/03 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/09/03 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/12/23 00:00 [accepted]
PHST- 2012/12/09 00:00 [revised]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2013 Aug 28;12(4):391-6.