PMID- 23996980
OWN - NLM
STAT- MEDLINE
DCOM- 20150204
LR  - 20140414
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 3
IP  - 4
DP  - 2014 Apr
TI  - Immunologic and tissue biocompatibility of flexible/stretchable electronics and 
      optoelectronics.
PG  - 515-25
LID - 10.1002/adhm.201300220 [doi]
AB  - Recent development of flexible/stretchable integrated electronic sensors and 
      stimulation systems has the potential to establish an important paradigm for 
      implantable electronic devices, where shapes and mechanical properties are 
      matched to those of biological tissues and organs. Demonstrations of tissue and 
      immune biocompatibility are fundamental requirements for application of such 
      kinds of electronics for long-term use in the body. Here, a comprehensive set of 
      experiments studies biocompatibility on four representative flexible/stretchable 
      device platforms, selected on the basis of their versatility and relevance in 
      clinical usage. The devices include flexible silicon field effect transistors 
      (FETs) on polyimide and stretchable silicon FETs, InGaN light-emitting diodes 
      (LEDs), and AlInGaPAs LEDs, each on low modulus silicone substrates. Direct 
      cytotoxicity measured by exposure of a surrogate fibroblast line and leachable 
      toxicity by minimum essential medium extraction testing reveal that all of these 
      devices are non-cytotoxic. In vivo immunologic and tissue biocompatibility 
      testing in mice indicate no local inflammation or systemic immunologic responses 
      after four weeks of subcutaneous implantation. The results show that these new 
      classes of flexible implantable devices are suitable for introduction into 
      clinical studies as long-term implantable electronics.
CI  - (c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Park, Gayoung
AU  - Park G
AD  - Global Research Laboratory, Department of Biochemistry and Molecular Biology, 
      Korea University College of Medicine, Seoul, 136-713, Republic of Korea.
FAU - Chung, Hyun-Joong
AU  - Chung HJ
FAU - Kim, Kwanghee
AU  - Kim K
FAU - Lim, Seon Ah
AU  - Lim SA
FAU - Kim, Jiyoung
AU  - Kim J
FAU - Kim, Yun-Soung
AU  - Kim YS
FAU - Liu, Yuhao
AU  - Liu Y
FAU - Yeo, Woon-Hong
AU  - Yeo WH
FAU - Kim, Rak-Hwan
AU  - Kim RH
FAU - Kim, Stanley S
AU  - Kim SS
FAU - Kim, Jong-Seon
AU  - Kim JS
FAU - Jung, Yei Hwan
AU  - Jung YH
FAU - Kim, Tae-Il
AU  - Kim TI
FAU - Yee, Cassian
AU  - Yee C
FAU - Rogers, John A
AU  - Rogers JA
FAU - Lee, Kyung-Mi
AU  - Lee KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130901
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Biocompatible Materials)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry/toxicity
MH  - Cell Survival/drug effects
MH  - Cytokines/blood
MH  - *Electronics, Medical
MH  - Female
MH  - Leukocytes, Mononuclear/drug effects/immunology/metabolism
MH  - Materials Testing
MH  - Mice
MH  - Pliability
MH  - *Prostheses and Implants
OTO - NOTNLM
OT  - biocompatible electronics
OT  - implantation
OT  - sensors
EDAT- 2013/09/03 06:00
MHDA- 2015/02/05 06:00
CRDT- 2013/09/03 06:00
PHST- 2013/06/05 00:00 [received]
PHST- 2013/06/29 00:00 [revised]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2015/02/05 06:00 [medline]
AID - 10.1002/adhm.201300220 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2014 Apr;3(4):515-25. doi: 10.1002/adhm.201300220. Epub 2013 
      Sep 1.