PMID- 23997528
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130902
LR  - 20211021
IS  - 1000-9604 (Print)
IS  - 1993-0631 (Electronic)
IS  - 1000-9604 (Linking)
VI  - 25
IP  - 4
DP  - 2013 Aug
TI  - PIK3CA mutation in Chinese patients with lung squamous cell carcinoma.
PG  - 416-22
LID - 10.3978/j.issn.1000-9604.2013.08.03 [doi]
AB  - OBJECTIVE: To investigate PIK3CA mutation in Chinese patients with lung squamous 
      cell carcinoma (LSCC) and explore their relationship with clinicopathological 
      profiles. METHODS: Tumor samples from 123 cases of LSCC were included in this 
      study. PIK3CA mutations in exon 9 and 20 were screened by pyrosequencing and 
      confirmed by clone sequencing or amplification refractory mutation system (ARMS). 
      Denaturing performance liquid chromatography (DHPLC) was employed for evaluation 
      of EGFR mutation in exon 19, 21 and KRAS mutation. RESULTS: PIK3CA mutations were 
      found in 3 (2.4%) patients. The mutation type included E545K, E452Q and H1047R. 
      Of these three patients, one coupled with EGFR mutation, and the other two 
      coupled with PIK3CA amplification. All the three patients shared the same 
      clinicopathologic characteristics: male, less than 60 years old, had smoke 
      history, stage III and carried wild-type KRAS. CONCLUSIONS: The frequency of 
      PIK3CA mutation is low in Chinese patients with LSCC. The mutational status of 
      PIK3CA is not mutually exclusive to EGFR mutation.
FAU - Yu, Jinglin
AU  - Yu J
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education), Department of Thoracic Medical Oncology, Peking University Cancer 
      Hospital & Institute, Beijing 100142, China.
FAU - Bai, Hua
AU  - Bai H
FAU - Wang, Zhijie
AU  - Wang Z
FAU - Wei, Zhigang
AU  - Wei Z
FAU - Ding, Xiaosheng
AU  - Ding X
FAU - Duan, Jianchun
AU  - Duan J
FAU - Yang, Lu
AU  - Yang L
FAU - Wu, Meina
AU  - Wu M
FAU - Wang, Yuyan
AU  - Wang Y
FAU - Wang, Jie
AU  - Wang J
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin J Cancer Res
JT  - Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
JID - 9315242
PMC - PMC3752364
OTO - NOTNLM
OT  - EGFR mutation
OT  - KRAS mutation
OT  - Lung squamous cell carcinoma (LSCC)
OT  - PIK3CA mutation
EDAT- 2013/09/03 06:00
MHDA- 2013/09/03 06:01
PMCR- 2013/08/01
CRDT- 2013/09/03 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2013/09/03 06:01 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - cjcr-25-04-416 [pii]
AID - 10.3978/j.issn.1000-9604.2013.08.03 [doi]
PST - ppublish
SO  - Chin J Cancer Res. 2013 Aug;25(4):416-22. doi: 
      10.3978/j.issn.1000-9604.2013.08.03.