PMID- 23997903
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130902
LR  - 20211021
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 16
IP  - 6
DP  - 2013 Jun
TI  - Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive 
      and Psychological Markers in Elderly in Northeasten of Iran.
PG  - 772-80
AB  - OBJECTIVE(S): Incidence of neurocognitive and psychological disorders may be 
      related to serum homocystein (Hcy), cobalamin (vitamin B12) and folate levels in 
      old people. The aim of this study was to assess the relation between Hcy, 
      cobalamin, folate and neurocognitive and/or psychological disorders in the 
      elderly. MATERIALS AND METHODS: In this cross-sectional study, 280 subjects with 
      >/= 65 years old ,were evaluated. The subjects were selected from 12 regions of 
      Mashhad, Iran, over March to October 2009. After blood sampling, data were 
      collected by questionnaire, face to face interview and performing neurocognitive 
      and psychological tests. The sera of 250 persons were analyzed for cobalamin and 
      folate by RIA method. Amongst the aforementioned samples, 78 cases with cobalamin 
      <300 pg/ml and folate <6.5 ng/ml were analyzed for Hcy by ELISA method. RESULTS: 
      Amongst the people, 126 (45%) were male and 154 (55%) were female. The prevalence 
      of hyperhomocysteinemia (HHcy) was 59.5% and 37.1% in male and female 
      respectively (P -value =0.049). Hcy inversely correlated to cobalamin (r=-0.282, 
      P=0.014) and to folate (r=-0.203, P=0.014). Hcy, cobalamin and folate 
      correlations to neurocognitive and psychological impairments were not statically 
      significant. CONCLUSION: Hyper Hcy or low cobalamin and folate in the elderly, 
      are prevalent but their relationships with neurocognitive and psychological 
      impairments is controversial. If these relationships had been confirmed, 
      performing a single serum Hcy or cobalamin test would have been enough enough to 
      diagnose and prevent neurocognitive impairments and inversely, 
      neurocognitive-psychological sign and symptoms could have meant probable tissue 
      vitamin deficiencies. However methods of assessing neurocognitive and 
      psychological markers with validity and reliability of clinical and laboratory 
      tests for finding aforementioned relationships should be revised.
FAU - Manavifar, Lida
AU  - Manavifar L
AD  - Paramedical School, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Nemati Karimooy, Habibollah
AU  - Nemati Karimooy H
FAU - Jamali, Jamshid
AU  - Jamali J
FAU - Talebi Doluee, Morteza
AU  - Talebi Doluee M
FAU - Shirdel, Abbas
AU  - Shirdel A
FAU - Nejat Shokohi, Amireh
AU  - Nejat Shokohi A
FAU - Fatemi Nayyeri, Mahdie
AU  - Fatemi Nayyeri M
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3758032
OTO - NOTNLM
OT  - Cobalamin
OT  - Folate
OT  - Homocystein
OT  - Neurocognitive
OT  - Psychological
OT  - The elderly
EDAT- 2013/09/03 06:00
MHDA- 2013/09/03 06:01
PMCR- 2013/06/01
CRDT- 2013/09/03 06:00
PHST- 2012/05/26 00:00 [received]
PHST- 2012/08/19 00:00 [accepted]
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2013/09/03 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - ijbms-16-722 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2013 Jun;16(6):772-80.