PMID- 23998234
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20231110
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 34
IP  - 5
DP  - 2013 Sep-Oct
TI  - Prenatal determinants of cord blood total immunoglobulin E levels in Mexican 
      newborns.
PG  - e27-34
LID - 10.2500/aap.2013.34.3688 [doi]
AB  - Asthma and allergic diseases have increased worldwide; however, etilogic factors 
      for this increase are still poor. Prenatal consumptions of fatty acids are 
      hypothesized, although few clinical trials in developing countries have been 
      performed. This study was designed to identify predictors of immunoglobulin E 
      (IgE) levels in cord blood of Mexican newborns. Total IgE was measured in 
      umbilical cord blood from 613 infants whose mothers participated in a 
      double-blind randomized controlled trial of 400 mg of docosahexaenoic acid or 
      placebo from 18 to 22 weeks gestation through delivery. During pregnancy, 
      information on sociodemographic characteristics, environmental exposures, and 
      perceived maternal stress were obtained; a maternal blood sample was also 
      collected to determine atopy via specific IgE levels. Logistic regression models 
      were used to identify the main prenatal predictors of detectable total IgE levels 
      in cord blood. IgE was detectable in cord blood from 344 (53.7%) infants; the 
      main predictors in multivariate analyses were maternal atopy (odds ratio [OR] = 
      1.69; 95% CI, 1.19-2.42; p < 0.05) and pesticide use in the home (OR = 1.49; 95% 
      CI, 1.04-2.14; p < 0.05). When stratified by maternal atopy, season of birth was 
      a significant predictor in the atopic group only (OR = 2.48; 95% CI, 1.00-6.16; p 
      < 0.05), and pesticide use was a significant predictor for infants born to 
      nonatopic mothers (OR = 1.64; 95% CI, 1.07-2.51; p < 0.05). No differences were 
      seen in the proportion of infants with detectable IgE by treatment group. 
      Prenatal supplementation with omega-3 polyunsaturated fatty acid did not alter 
      the detectable cord blood IgE levels. Maternal atopy and pesticide use during 
      pregnancy are strong predictors of cord blood IgE levels in newborns. Clinical 
      trial NCT00646360, www.clinicaltrials.gov.
FAU - Hernandez, Evelia
AU  - Hernandez E
AD  - Instituto Nacional de Salud Publica, Salud Ambiental, Cuernavaca, Morelos, 
      Mexico.
FAU - Barraza-Villarreal, Albino
AU  - Barraza-Villarreal A
FAU - Escamilla-Nunez, Maria Consuelo
AU  - Escamilla-Nunez MC
FAU - Hernandez-Cadena, Leticia
AU  - Hernandez-Cadena L
FAU - Sly, Peter D
AU  - Sly PD
FAU - Neufeld, Lynnette Marie
AU  - Neufeld LM
FAU - Ramakishnan, Usha
AU  - Ramakishnan U
FAU - Romieu, Isabelle
AU  - Romieu I
LA  - eng
SI  - ClinicalTrials.gov/NCT00646360
GR  - R01 HD058818/HD/NICHD NIH HHS/United States
GR  - R01HD058818/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 0 (Epitopes)
RN  - 0 (Pesticides)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/immunology/*metabolism
MH  - Animals
MH  - Biomarkers/*metabolism
MH  - Docosahexaenoic Acids/administration & dosage
MH  - Epitopes/immunology/*metabolism
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Humans
MH  - Hypersensitivity/*diagnosis/etiology/therapy
MH  - Immunoglobulin E/blood/immunology
MH  - Infant, Newborn
MH  - Male
MH  - Mexico
MH  - Pesticides/immunology/*metabolism
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Prognosis
MH  - Young Adult
PMC - PMC3973815
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2013/09/04 06:00
MHDA- 2014/04/23 06:00
PMCR- 2013/09/01
CRDT- 2013/09/04 06:00
PHST- 2013/09/04 06:00 [entrez]
PHST- 2013/09/04 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - AAP271-12 [pii]
AID - 10.2500/aap.2013.34.3688 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2013 Sep-Oct;34(5):e27-34. doi: 10.2500/aap.2013.34.3688.