PMID- 23998927
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20131122
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 95
IP  - 3
DP  - 2013 Dec
TI  - Molecular evolution of porcine reproductive and respiratory syndrome virus 
      isolates from central China.
PG  - 908-12
LID - S0034-5288(13)00279-8 [pii]
LID - 10.1016/j.rvsc.2013.07.029 [doi]
AB  - To investigate the genetic diversity of prevailing porcine reproductive and 
      respiratory syndrome virus (PRRSV) in Henan Province of China, 61 ORF5 gene 
      sequences, originating from Henan Province during 2003-2010, were subjected to 
      amino acid variation and phylogenetic analysis. The analyzed PRRSV ORF5 sequences 
      carried evidence of one unique recombination event. Phylogenetic analysis 
      revealed that all Henan isolates belonged to type 2 genotype and were divided 
      into two subgroups. The dominant isolates had shifted from subgroup 1 to subgroup 
      2 during 2003-2010. Amino acid variation analysis of the glycoprotein 5 revealed 
      that Henan PRRSV strains tended to accumulate more substitutions within the 
      N-terminus and hypervariable region. Selective pressure analysis revealed 
      evidence that some ORF5 sites have likely evolved in response to immune pressure.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Mu, Chunlong
AU  - Mu C
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou 450002, China; College of Animal Science and Technology, Nanjing 
      Agricultural University, Nanjing 210095, China.
FAU - Lu, Xiaoyan
AU  - Lu X
FAU - Duan, Erzhen
AU  - Duan E
FAU - Chen, Jing
AU  - Chen J
FAU - Li, Weijuan
AU  - Li W
FAU - Zhang, Fenghua
AU  - Zhang F
FAU - Martin, Darren P
AU  - Martin DP
FAU - Yang, Mingfan
AU  - Yang M
FAU - Xia, Pingan
AU  - Xia P
FAU - Cui, Baoan
AU  - Cui B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130806
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein 5, PRRSV)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - China/epidemiology
MH  - Evolution, Molecular
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Sequence Alignment/veterinary
MH  - Swine
MH  - Viral Envelope Proteins/genetics
OTO - NOTNLM
OT  - Genetic variation
OT  - ORF5
OT  - PRRSV
OT  - Phylogenetic analysis
EDAT- 2013/09/04 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/09/04 06:00
PHST- 2012/07/05 00:00 [received]
PHST- 2013/07/19 00:00 [revised]
PHST- 2013/07/28 00:00 [accepted]
PHST- 2013/09/04 06:00 [entrez]
PHST- 2013/09/04 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - S0034-5288(13)00279-8 [pii]
AID - 10.1016/j.rvsc.2013.07.029 [doi]
PST - ppublish
SO  - Res Vet Sci. 2013 Dec;95(3):908-12. doi: 10.1016/j.rvsc.2013.07.029. Epub 2013 
      Aug 6.