PMID- 23999131
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20240518
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 91
IP  - 9
DP  - 2013 Oct
TI  - Aryl hydrocarbon receptor signaling regulates NF-kappaB RelB activation during 
      dendritic-cell differentiation.
PG  - 568-75
LID - 10.1038/icb.2013.43 [doi]
AB  - How the aryl hydrocarbon receptor (AhR) regulates dendritic-cell (DC) 
      differentiation is unknown. We show that activation of AhR by 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused enhanced differentiation from 
      immature DCs (IDCs) to mature DCs (MDCs) in the bone-marrow-derived DCs (BMDC) 
      from B6 wild-type mice but not in the BMDCs from AhR-null mice as indicated by 
      the expression of CD11c and class II major histocompatibility complex (MHC). 
      Enhanced maturation of BMDCs was associated with elevated levels of CD86 and an 
      increased AhR-dependent nuclear accumulation of nuclear factor-kappa-light-chain 
      enhancer of activated B cell (NF-kappaB) member RelB in BMDCs. The expression of 
      interleukin (IL) 10 and chemokine DC-CK1 was suppressed, whereas that of CXCL2, 
      CXCL3 and IL-22 was significantly increased in AhR-activated BMDCs. Furthermore, 
      TCDD induced expression of the regulatory enzymes indoleamine 2,3-dioxygenase 
      (IDO1) and indoleamine 2,3-dioxygenase-like 1 (IDO2). Increased expression of 
      IDO2 was associated with coexpression of the cell-surface marker CCR6. 
      Interestingly, mRNA expression of the chemokine receptor CCR6 was drastically 
      decreased in AhR-null IDCs and MDCs. Overall, these data demonstrate that AhR 
      modifies the maturation of BMDCs associated with the induction of the regulatory 
      enzyme IDO and altered expression of cytokine, chemokines and DC-specific surface 
      markers and receptors.
FAU - Vogel, Christoph F A
AU  - Vogel CF
AD  - 1] Department of Environmental Toxicology, University of California at Davis, 
      Davis, CA, USA [2] Center for Health and the Environment, University of 
      California at Davis, Davis, CA, USA.
FAU - Wu, Dalei
AU  - Wu D
FAU - Goth, Samuel R
AU  - Goth SR
FAU - Baek, Jaeeun
AU  - Baek J
FAU - Lollies, Anna
AU  - Lollies A
FAU - Domhardt, Rowena
AU  - Domhardt R
FAU - Grindel, Annemarie
AU  - Grindel A
FAU - Pessah, Isaac N
AU  - Pessah IN
LA  - eng
GR  - P01ES011269/ES/NIEHS NIH HHS/United States
GR  - P01 ES011269/ES/NIEHS NIH HHS/United States
GR  - R01ES019898/ES/NIEHS NIH HHS/United States
GR  - 5R21ES015846/ES/NIEHS NIH HHS/United States
GR  - R21 ES015846/ES/NIEHS NIH HHS/United States
GR  - R01 ES019898/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130903
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (CCR6 protein, mouse)
RN  - 0 (Chemokines)
RN  - 0 (IDO1 protein, mouse)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Interleukins)
RN  - 0 (NF-kappa B)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Receptors, CCR6)
RN  - 0 (Relb protein, mouse)
RN  - 130068-27-8 (Interleukin-10)
RN  - 147337-75-5 (Transcription Factor RelB)
SB  - IM
CIN - Immunol Cell Biol. 2013 Oct;91(9):543-4. PMID: 24108273
MH  - Animals
MH  - Cell Differentiation/drug effects/genetics
MH  - Cells, Cultured
MH  - Chemokines/genetics/metabolism
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Gene Expression Regulation/genetics/immunology
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism
MH  - Interleukin-10/genetics/metabolism
MH  - Interleukins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - NF-kappa B/*metabolism
MH  - Polychlorinated Dibenzodioxins/pharmacology
MH  - Receptors, Aryl Hydrocarbon/genetics/immunology/*metabolism
MH  - Receptors, CCR6/metabolism
MH  - Signal Transduction/genetics
MH  - Transcription Factor RelB/*metabolism
MH  - Transcriptional Activation/genetics
MH  - Interleukin-22
PMC - PMC3806313
EDAT- 2013/09/04 06:00
MHDA- 2014/07/16 06:00
PMCR- 2013/10/23
CRDT- 2013/09/04 06:00
PHST- 2013/06/04 00:00 [received]
PHST- 2013/07/26 00:00 [revised]
PHST- 2013/07/27 00:00 [accepted]
PHST- 2013/09/04 06:00 [entrez]
PHST- 2013/09/04 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
PHST- 2013/10/23 00:00 [pmc-release]
AID - icb201343 [pii]
AID - 10.1038/icb.2013.43 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2013 Oct;91(9):568-75. doi: 10.1038/icb.2013.43. Epub 2013 Sep 
      3.