PMID- 24000094 OWN - NLM STAT- MEDLINE DCOM- 20131230 LR - 20211021 IS - 2168-6157 (Electronic) IS - 2168-6149 (Print) IS - 2168-6149 (Linking) VI - 70 IP - 11 DP - 2013 Nov TI - Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease. PG - 1382-8 LID - 10.1001/jamaneurol.2013.3487 [doi] AB - IMPORTANCE: Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown. OBJECTIVES: To determine if MeDi modifies the time to clinical onset of HD (phenoconversion) in premanifest carriers participating in Prospective Huntington at Risk Observational Study (PHAROS), and to examine the effects of body mass index and caloric intake on time to phenoconversion. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of 41 Huntington study group sites in the United States and Canada involving 1001 participants enrolled in PHAROS between July 1999 and January 2004 who were followed up every 9 months until 2010. A total of 211 participants aged 26 to 57 years had an expanded CAG repeat length (>/= 37). EXPOSURE: A semiquantitative food frequency questionnaire was administered 33 months after baseline. We calculated daily gram intake for dairy, meat, fruit, vegetables, legumes, cereals, fish, monounsaturated and saturated fatty acids, and alcohol and constructed MeDi scores (0-9); higher scores indicate higher adherence. Demographics, medical history, body mass index, and Unified Huntington's Disease Rating Scale (UHDRS) score were collected. MAIN OUTCOME AND MEASURE: Cox proportional hazards regression models to determine the association of MeDi and phenoconversion. RESULTS Age, sex, caloric intake, education status, and UHDRS motor scores did not differ among MeDi tertiles (0-3, 4-5, and 6-9). The highest body mass index was associated with the lowest adherence to MeDi. Thirty-one participants phenoconverted. In a model adjusted for age, CAG repeat length, and caloric intake, MeDi was not associated with phenoconversion (P for trend = 0.14 for tertile of MeDi, and P = .22 for continuous MeDi). When individual components of MeDi were analyzed, higher dairy consumption (hazard ratio, 2.36; 95% CI, 1.0-5.57; P = .05) and higher caloric intake (P = .04) were associated with risk of phenoconversion. CONCLUSIONS AND RELEVANCE: MeDi was not associated with phenoconversion; however, higher consumption of dairy products had a 2-fold increased risk and may be a surrogate for lower urate levels (associated with faster progression in manifest HD). Studies of diet and energy expenditure in premanifest HD may provide data for interventions to modify specific components of diet that may delay the onset of HD. FAU - Marder, Karen AU - Marder K AD - Departments of Neurology and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York3Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, New York. FAU - Gu, Yian AU - Gu Y FAU - Eberly, Shirley AU - Eberly S FAU - Tanner, Caroline M AU - Tanner CM FAU - Scarmeas, Nikolaos AU - Scarmeas N FAU - Oakes, David AU - Oakes D FAU - Shoulson, Ira AU - Shoulson I CN - Huntington Study Group PHAROS Investigators LA - eng GR - U01NS052592/NS/NINDS NIH HHS/United States GR - P0412196-G/PHS HHS/United States GR - UL1 RR024156/RR/NCRR NIH HHS/United States GR - R01 NS075321/NS/NINDS NIH HHS/United States GR - R01 HG002449-06/HG/NHGRI NIH HHS/United States GR - R01 HG002449/HG/NHGRI NIH HHS/United States GR - NS036630/NS/NINDS NIH HHS/United States GR - 1UL1RR024156-01/RR/NCRR NIH HHS/United States GR - R56 NS036630/NS/NINDS NIH HHS/United States GR - U01 NS052592/NS/NINDS NIH HHS/United States GR - R01 NS036630/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - JAMA Neurol JT - JAMA neurology JID - 101589536 SB - IM MH - Adult MH - Body Mass Index MH - Canada MH - Diet, Mediterranean MH - Disease Progression MH - Energy Intake/*physiology MH - Female MH - Humans MH - Huntington Disease/*complications/genetics/*prevention & control MH - Male MH - *Medication Adherence MH - Middle Aged MH - Observation MH - Phenotype MH - Predictive Value of Tests MH - Proportional Hazards Models MH - Prospective Studies MH - Retrospective Studies MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Time Factors MH - Trinucleotide Repeat Expansion/genetics MH - United States PMC - PMC4040231 MID - NIHMS587427 COIS- Disclosures: The authors report no conflict of interest FIR - Shoulson, Ira IR - Shoulson I FIR - Kieburtz, Karl IR - Kieburtz K FIR - Oakes, David IR - Oakes D FIR - Kayson, Elise IR - Kayson E FIR - Zhao, Hongwei IR - Zhao H FIR - Shinaman, M Aileen IR - Shinaman M FIR - Romer, Megan IR - Romer M FIR - Young, Anne IR - 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Poiffaut, Hubert IR - Poiffaut H FIR - Rioux, Brigitte IR - Rioux B FIR - Testa, Claudia IR - Testa C FIR - Greenamyre, Timothy IR - Greenamyre T FIR - Harrison, Joan IR - Harrison J FIR - Corey-Bloom, Jody IR - Corey-Bloom J FIR - Song, David IR - Song D FIR - Peavy, Guerry IR - Peavy G FIR - Goldstein, Jody IR - Goldstein J FIR - Paulsen, Jane IR - Paulsen J FIR - Paulson, Henry IR - Paulson H FIR - Rodnitzky, Robert L IR - Rodnitzky RL FIR - Mikos, Ania IR - Mikos A FIR - Reese, Becky IR - Reese B FIR - Stierman, Laura IR - Stierman L FIR - Williams, Katie IR - Williams K FIR - Vining, Lynn IR - Vining L FIR - Marder, Karen IR - Marder K FIR - Moskowitz, Carol IR - Moskowitz C FIR - Quaid, Kimberly IR - Quaid K FIR - Wojcieszek, Joanne IR - Wojcieszek J FIR - Wesson, Melissa IR - Wesson M FIR - Samii, Ali IR - Samii A FIR - Bird, Thomas IR - Bird T FIR - Lipe, Hillary IR - Lipe H FIR - Reynolds, Norman IR - Reynolds N FIR - Blindauer, Karen IR - Blindauer K FIR - Petit, Jeannine IR - Petit J FIR - Como, Peter IR - Como P FIR - Marshall, Frederick IR - Marshall F FIR - Counihan, Timothy IR - Counihan T FIR - Biglan, Kevin IR - Biglan K FIR - Zimmerman, Carol IR - Zimmerman C FIR - Hogarth, Penelope IR - Hogarth P FIR - Nutt, John IR - Nutt J FIR - Andrews, Pamela IR - Andrews P FIR - Hersch, Steven IR - Hersch S FIR - Shinobu, Leslie IR - Shinobu L FIR - Rosas, Diana IR - Rosas D FIR - Kaneko, Yoshio IR - Kaneko Y FIR - Gevorkian, Sona IR - Gevorkian S FIR - Sexton, Paula IR - Sexton P FIR - Caviness, John IR - Caviness J FIR - Adler, Charles IR - Adler C FIR - Wheelock, Vicki IR - Wheelock V FIR - Richman, David IR - Richman D FIR - Tempkin, Teresa IR - Tempkin T FIR - Wu, Chuang-Kuo IR - Wu CK FIR - Fernandez, Hubert IR - Fernandez H FIR - Friedman, Joseph H IR - Friedman JH FIR - Lannon, Margaret IR - Lannon M FIR - Seeberger, Lauren IR - Seeberger L FIR - O'Brien, Christopher IR - O'Brien C FIR - Montellano, Sherrie IR - Montellano S FIR - Kartha, Ninith IR - Kartha N FIR - Sakurai, Sharin IR - Sakurai S FIR - Hickenbottom, Susan IR - Hickenbottom S FIR - Albin, Roger IR - Albin R FIR - Wernette, Kristine IR - Wernette K FIR - Racette, Brad IR - Racette B FIR - Perlmutter, Joel S IR - Perlmutter JS FIR - Good, Laura IR - Good L FIR - Jackson, George IR - Jackson G FIR - Perlman, Susan IR - Perlman S FIR - Segal, Shelley IR - Segal S FIR - Carroll, Russell IR - Carroll R FIR - Carr, Laurie IR - Carr L FIR - Martin, Wayne IR - Martin W FIR - Roberts, Ted IR - Roberts T FIR - Wieler, Marguerite IR - Wieler M FIR - Leavitt, Blair IR - Leavitt B FIR - Clarke, Lorne IR - Clarke L FIR - Raymond, Lynn IR - Raymond L FIR - Decolongon, Joji IR - Decolongon J FIR - Popovska, Vesna IR - Popovska V FIR - Almqvist, Elisabeth IR - Almqvist E FIR - Ondo, William IR - Ondo W FIR - Thomas, Madhavi IR - Thomas M FIR - Ashizawa, Tetsuo IR - Ashizawa T FIR - Jankovic, Joseph IR - Jankovic J FIR - Hauser, Robert IR - Hauser R FIR - Sanchez-Ramos, Juan IR - Sanchez-Ramos J FIR - Price, Karen IR - Price K FIR - Delgado, Holly IR - Delgado H FIR - Furtado, Sarah IR - Furtado S FIR - LaFontaine, Anne Louise IR - LaFontaine AL FIR - Suchowersky, Oksana IR - Suchowersky O FIR - Klimek, Mary Lou IR - Klimek ML FIR - Sethna, Rustom IR - Sethna R FIR - Guttman, Mark IR - Guttman M FIR - Russell, Sandra IR - Russell S FIR - Elliott, Sheryl IR - Elliott S FIR - Mentis, Marc IR - Mentis M FIR - Feigin, Andrew IR - Feigin A FIR - Cox, Marie IR - Cox M FIR - Shannon, Barbara IR - Shannon B FIR - Percy, Alan IR - Percy A FIR - Dure, Leon IR - Dure L FIR - Pendley, Donna IR - Pendley D FIR - Lane, Jane IR - Lane J FIR - Harrison, Madaline IR - Harrison M FIR - Rost-Ruffner, Elke IR - Rost-Ruffner E FIR - Johnson, William IR - Johnson W FIR - Colcher, Amy IR - Colcher A FIR - Siderowf, Andrew IR - Siderowf A FIR - Matthews, Mary IR - Matthews M FIR - Jennings, Danna IR - Jennings D FIR - Marek, Kenneth IR - Marek K FIR - Caplan, Karen IR - Caplan K FIR - Higgins, Donald IR - 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Vickers, Leslie IR - Vickers L FIR - Deckel, Wallace IR - Deckel W FIR - Duffy, James IR - Duffy J FIR - Fitzpatrick, Mary Jane IR - Fitzpatrick MJ FIR - Thomson, Elizabeth IR - Thomson E FIR - Hersch, Steven IR - Hersch S FIR - Stout, Julie IR - Stout J FIR - Calhoun, James IR - Calhoun J FIR - Coryell, William IR - Coryell W FIR - Erwin, Cheryl IR - Erwin C FIR - Hunt, Vicki IR - Hunt V FIR - Ross, Christopher IR - Ross C FIR - Vawter, Dorothy IR - Vawter D FIR - Andrews, Lori IR - Andrews L FIR - Bury, Debbie IR - Bury D FIR - Calhoun, James IR - Calhoun J FIR - Hersch, Steven IR - Hersch S FIR - Hunt, Vicki IR - Hunt V FIR - Leventhal, Carl IR - Leventhal C FIR - Quaid, Kimberly IR - Quaid K FIR - Shinaman, Aileen IR - Shinaman A FIR - Vawter, Dorothy IR - Vawter D FIR - Wexler, Nancy IR - Wexler N FIR - Brocht, Alicia IR - Brocht A FIR - Daigneault, Susan IR - Daigneault S FIR - Gerwitz, Karen IR - Gerwitz K FIR - Orme, Connie IR - Orme C FIR - Nobel, Ruth IR - Nobel R FIR - Ross, Victoria IR - Ross V FIR - Slough, Mary IR - Slough M FIR - Watts, Arthur IR - Watts A FIR - Weber, Joe IR - Weber J FIR - Weaver, Christine IR - Weaver C FIR - Julian-Baros, Elaine IR - Julian-Baros E FIR - Young, Anne IR - Young A FIR - Marder, Karen IR - Marder K FIR - Foroud, Tatiana IR - Foroud T FIR - Gusella, James IR - Gusella J FIR - Housman, David IR - Housman D FIR - MacDonald, Marcy IR - MacDonald M FIR - Myers, Richard IR - Myers R FIR - Tanner, Caroline IR - Tanner C FIR - Tanzi, Rudolph IR - Tanzi R FIR - Fahn, Stanley IR - Fahn S FIR - Conneally, Michael IR - Conneally M FIR - Tsai, Weiu-Yann IR - Tsai WY FIR - Housman, David IR - Housman D FIR - Ross, Christopher IR - Ross C FIR - Tanzi, Rudolph IR - Tanzi R FIR - Young, Anne IR - Young A FIR - Kawas, Claudia IR - Kawas C FIR - Francoise-Chesselet, Marie IR - Francoise-Chesselet M FIR - Conneally, Michael IR - Conneally M FIR - Nance, Martha IR - Nance M FIR - Shults, Clifford IR - Shults C FIR - Tanner, Caroline IR - Tanner C FIR - Hogarth, Penelope IR - Hogarth P FIR - Rosas, Diana IR - Rosas D FIR - Zhao, Hongwei IR - Zhao H EDAT- 2013/09/04 06:00 MHDA- 2014/01/01 06:00 PMCR- 2014/06/01 CRDT- 2013/09/04 06:00 PHST- 2013/09/04 06:00 [entrez] PHST- 2013/09/04 06:00 [pubmed] PHST- 2014/01/01 06:00 [medline] PHST- 2014/06/01 00:00 [pmc-release] AID - 1733320 [pii] AID - 10.1001/jamaneurol.2013.3487 [doi] PST - ppublish SO - JAMA Neurol. 2013 Nov;70(11):1382-8. doi: 10.1001/jamaneurol.2013.3487.