PMID- 24000814
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20220331
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Print)
IS  - 0271-3683 (Linking)
VI  - 38
IP  - 12
DP  - 2013 Dec
TI  - Effect of contact lens on optical coherence tomography imaging of rodent retina.
PG  - 1235-40
LID - 10.3109/02713683.2013.815218 [doi]
AB  - PURPOSE: To evaluate the effect of powerless contact lens on improving the 
      quality of optical coherence tomography imaging of rodent retina. METHODS: A 
      spectral-domain optical coherence tomography (SD-OCT) system was built for in 
      vivo imaging of rodent retina. The calibrated depth resolution of the system was 
      3 microm in tissue. A commercial powerless contact lens for rat eye was tested in the 
      experiments. For each rat eye, the retina was imaged in vivo sequentially first 
      without wearing contact lens and then with wearing contact lens. The lateral 
      resolution and signal-to-noise ratio of the OCT images with and without contact 
      lens were compared to evaluate the improvement of image quality. RESULTS: The 
      fundus images generated from the measured 3D OCT datasets with contact lens 
      showed sharper retinal blood vessels than those without contact lens. The 
      contrast of the retinal blood vessels was also significantly enhanced in the OCT 
      fundus images with contact lens. As high as 10 dB improvements in SNR was 
      observed for OCT images with contact lens compared to the images of the same 
      retinal area without contact lens. CONCLUSIONS: We have demonstrated that the use 
      of powerless contact lens on rat eye can significantly improve OCT image quality 
      of rodent retina, which is a benefit in addition to preventing cataract 
      formation. We believe the improvement in image quality is the result of partial 
      compensation of the optical aberrations of the rodent eye by the contact lens.
FAU - Liu, Xiaojing
AU  - Liu X
AD  - Department of Biomedical Engineering, Florida International University , Miami, 
      FL , USA .
FAU - Wang, Chia-Hao
AU  - Wang CH
FAU - Dai, Cuixia
AU  - Dai C
FAU - Camesa, Adam
AU  - Camesa A
FAU - Zhang, Hao F
AU  - Zhang HF
FAU - Jiao, Shuliang
AU  - Jiao S
LA  - eng
GR  - R01 EY019951/EY/NEI NIH HHS/United States
GR  - 5R01EY019951-03/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130903
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Animals
MH  - *Contact Lenses
MH  - Corneal Wavefront Aberration/*prevention & control
MH  - Equipment Design
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retina/*anatomy & histology
MH  - Retinal Vessels/*anatomy & histology
MH  - Signal-To-Noise Ratio
MH  - Tomography, Optical Coherence/*instrumentation/*methods
PMC - PMC4291550
MID - NIHMS650602
COIS- DECLARATION OF INTEREST This work is supported in part by the following grants: 
      National Institutes of Health grant 5R01EY019951-03 and Coulter Translational 
      Award. There are no conflicts of interest in this paper. The authors alone are 
      responsible for the content and writing of the paper.
EDAT- 2013/09/05 06:00
MHDA- 2014/06/15 06:00
PMCR- 2015/01/13
CRDT- 2013/09/05 06:00
PHST- 2013/09/05 06:00 [entrez]
PHST- 2013/09/05 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
PHST- 2015/01/13 00:00 [pmc-release]
AID - 10.3109/02713683.2013.815218 [doi]
PST - ppublish
SO  - Curr Eye Res. 2013 Dec;38(12):1235-40. doi: 10.3109/02713683.2013.815218. Epub 
      2013 Sep 3.