PMID- 24002196
OWN - NLM
STAT- MEDLINE
DCOM- 20140414
LR  - 20211021
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 5
IP  - 9
DP  - 2013 Sep 2
TI  - Effects of dietary zinc manipulation on growth performance, zinc status and 
      immune response during Giardia lamblia infection: a study in CD-1 mice.
PG  - 3447-60
LID - 10.3390/nu5093447 [doi]
AB  - Associations between Giardia lamblia infection and low serum concentrations of 
      zinc have been reported in young children. Interestingly, relatively few studies 
      have examined the effects of different dietary zinc levels on the 
      parasite-infected host. The aims of this study were to compare the growth 
      performance and zinc status in response to varying levels of dietary zinc and to 
      measure the antibody-mediated response of mice during G. lamblia infection. Male 
      CD-1 mice were fed using 1 of 4 experimental diets: adequate-zinc (ZnA), low-zinc 
      (ZnL), high-zinc (ZnH) and supplemented-zinc (ZnS) diet containing 30, 10, 223 
      and 1383 mg Zn/kg respectively. After a 10 days feeding period, mice were 
      inoculated orally with 5 x 106 G. lamblia trophozoites and were maintained on the 
      assigned diet during the course of infection (30 days). Giardia-free mice fed ZnL 
      diets were able to attain normal growth and antibody-mediated response. 
      Giardia-infected mice fed ZnL and ZnA diets presented a significant growth 
      retardation compared to non-infected controls. Zinc supplementation avoided this 
      weight loss during G. lamblia infection and up-regulated the host's humoral 
      immune response by improving the production of specific antibodies. Clinical 
      outcomes of zinc supplementation during giardiasis included significant weight 
      gain, higher anti-G. lamblia IgG antibodies and improved serum zinc levels 
      despite the ongoing infection. A maximum growth rate and antibody-mediated 
      response were attained in mice fed ZnH diet. No further increases in body weight, 
      zinc status and humoral immune capacity were noted by feeding higher zinc levels 
      (ZnS) than the ZnH diet. These findings probably reflect biological effect of 
      zinc that could be of public health importance in endemic areas of infection.
FAU - Inigo-Figueroa, Gemma
AU  - Inigo-Figueroa G
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, Centro de 
      Investigacion en Alimentacion y Desarrollo, A.C. Carretera a La Victoria Km 0.6, 
      Hermosillo, Sonora C.P. 83304, Mexico. hastiazaran@ciad.mx.
FAU - Mendez-Estrada, Rosa O
AU  - Mendez-Estrada RO
FAU - Quihui-Cota, Luis
AU  - Quihui-Cota L
FAU - Velasquez-Contreras, Carlos A
AU  - Velasquez-Contreras CA
FAU - Garibay-Escobar, Adriana
AU  - Garibay-Escobar A
FAU - Canett-Romero, Rafael
AU  - Canett-Romero R
FAU - Astiazaran-Garcia, Humberto
AU  - Astiazaran-Garcia H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130902
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Immunoglobulin G)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - *Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Diet
MH  - *Dietary Supplements
MH  - Disease Models, Animal
MH  - Giardia lamblia
MH  - Giardiasis/*immunology/metabolism
MH  - Immunity, Humoral
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Mice
MH  - Weight Gain/drug effects
MH  - Zinc/*administration & dosage/blood
PMC - PMC3798913
EDAT- 2013/09/05 06:00
MHDA- 2014/04/15 06:00
PMCR- 2013/09/01
CRDT- 2013/09/05 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2013/08/13 00:00 [revised]
PHST- 2013/08/15 00:00 [accepted]
PHST- 2013/09/05 06:00 [entrez]
PHST- 2013/09/05 06:00 [pubmed]
PHST- 2014/04/15 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - nu5093447 [pii]
AID - nutrients-05-03447 [pii]
AID - 10.3390/nu5093447 [doi]
PST - epublish
SO  - Nutrients. 2013 Sep 2;5(9):3447-60. doi: 10.3390/nu5093447.