PMID- 24003367
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130904
LR  - 20211021
IS  - 2005-3711 (Print)
IS  - 1598-7876 (Electronic)
IS  - 1225-8245 (Linking)
VI  - 53
IP  - 6
DP  - 2013 Jun
TI  - Epigenetic regulation in the brain after spinal cord injury : a comparative 
      study.
PG  - 337-41
LID - 10.3340/jkns.2013.53.6.337 [doi]
AB  - OBJECTIVE: After spinal cord injury (SCI), functional and structural 
      reorganization occurs at multiple levels of brain including motor cortex. 
      However, the underlying mechanism still remains unclear. The current study was 
      performed to investigate the alterations in the expression of the main regulators 
      of neuronal development, survival and death, in the brain following thoracic 
      contusive SCI in a mouse model. METHODS: Eight-week-old female imprinting control 
      region mice (n=60; 30-35 g) were used in this study. We analyzed the expression 
      levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell 
      line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone 
      deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. RESULTS: The 
      expression of BDNF levels were elevated significantly compared with control group 
      at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 
      2, 4 weeks compared with control group, but these difference were not significant 
      (p>0.05). The GDNF levels were elevated at 2 week compared with control group, 
      but these differences were not significant (p>0.05). The difference of HDAC1 
      levels were not significant at 2, 4 and 8 weeks compared with control group 
      (p>0.05). CONCLUSION: These results demonstrate that the upregulation of BDNF may 
      play on important role in brain reorganization after SCI.
FAU - Park, Bit-Na-Ri
AU  - Park BN
AD  - Department of Rehabilitation Medicine, Wonju Christian Hospital, Yonsei 
      University Wonju College of Medicine, Wonju, Korea.
FAU - Kim, Seok Won
AU  - Kim SW
FAU - Cho, Sung-Rae
AU  - Cho SR
FAU - Lee, Ji Yong
AU  - Lee JY
FAU - Lee, Young-Hee
AU  - Lee YH
FAU - Kim, Sung-Hoon
AU  - Kim SH
LA  - eng
PT  - Journal Article
DEP - 20130630
PL  - Korea (South)
TA  - J Korean Neurosurg Soc
JT  - Journal of Korean Neurosurgical Society
JID - 101467054
PMC - PMC3756125
OTO - NOTNLM
OT  - Brain
OT  - Brain derived neurotrophic factor
OT  - Epigenetic
OT  - Regulators
OT  - Spinal cord injury
EDAT- 2013/09/05 06:00
MHDA- 2013/09/05 06:01
PMCR- 2013/06/01
CRDT- 2013/09/05 06:00
PHST- 2013/01/08 00:00 [received]
PHST- 2013/04/03 00:00 [revised]
PHST- 2013/06/19 00:00 [accepted]
PHST- 2013/09/05 06:00 [entrez]
PHST- 2013/09/05 06:00 [pubmed]
PHST- 2013/09/05 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.3340/jkns.2013.53.6.337 [doi]
PST - ppublish
SO  - J Korean Neurosurg Soc. 2013 Jun;53(6):337-41. doi: 10.3340/jkns.2013.53.6.337. 
      Epub 2013 Jun 30.