PMID- 24004585
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20181023
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 42
IP  - 5
DP  - 2013 May
TI  - [Molecular genetic abnormalities of N-myc and C-myc in pediatric neuroblastic 
      tumors and clinical pathologic significance].
PG  - 299-304
LID - 10.3760/cma.j.issn.0529-5807.2013.05.003 [doi]
AB  - OBJECTIVE: To investigate the molecular genetic abnormalities of N-myc and C-myc, 
      and their clinical pathological implications in pediatric neuroblastic tumors 
      (NTs). METHODS: Abnormalities of N-myc were detected by interphase fluorescence 
      in situ hybridization (FISH) technique in 246 cases of NTs, including 
      neuroblastoma (NB,188 cases), ganglioneuroblastoma (GNB, 52 cases), 
      ganglioneuroma (GN, 6 cases), and their association with the histological typing 
      of the tumors and prognosis was analyzed. Abnormalities of C-myc were detected by 
      FISH in 133 cases of NTs. RESULTS: Of the 246 cases of NTs, N-myc amplification 
      was only found in 27 cases (11.0%, 27/246) of NB, but not in any cases of GNB or 
      GN (P < 0.05). 89.0% (219/246) N-myc non-amplification were found in NTs, and it 
      included N-myc gain in 175 cases (71.1%, 175/246) and normal N-myc in 44 cases 
      (17.9%, 44/246). Univariate analysis indicated significantly (P = 0.012) poorer 
      outcome in patients with N-myc amplification than N-myc non-amplification. 
      However no significant difference was observed between N-myc gain cases and 
      normal N-myc cases (P = 0.057). C-myc gain was found in 74 of 133 cases (55.6%) 
      of NTs; no C-myc amplification or translocation was detected. Forty percent 
      (6/15) of cases with N-myc amplification and 57.6% (68/118) of cases with N-myc 
      non-amplification were accompanied by C-myc gain. The difference between N-myc 
      amplification and non-amplification with C-myc gain was not significant (P > 
      0.05). Univariate analysis indicated that the outcome difference was not 
      statistically significant between C-myc gain cases and normal C-myc cases (P = 
      0.357). CONCLUSIONS: The incidence of N-myc amplification only found in NB is low 
      in pediatric NTs in China. Patients with N-myc amplification predict poorer 
      outcome. No amplification or translocation of C-myc is detected in NTs, whereas 
      C-myc gain is relatively common in NTs. There is no obvious association between 
      N-myc amplification and C-myc gain.
FAU - Cai, Rong-qin
AU  - Cai RQ
AD  - Department of Pathology, Basic Medical College, Capital Medical University, 
      Beijing, China.
FAU - Zhou, Chun-ju
AU  - Zhou CJ
FAU - Sun, Qin-nuan
AU  - Sun QN
FAU - Ma, Xiao-li
AU  - Ma XL
FAU - Wang, Miao
AU  - Wang M
FAU - Li, Yong
AU  - Li Y
FAU - Wang, Da-ye
AU  - Wang DY
FAU - Gong, Li-ping
AU  - Gong LP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
SB  - IM
MH  - Adrenal Gland Neoplasms/genetics/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Ganglioneuroblastoma/genetics/pathology
MH  - Ganglioneuroma/genetics/pathology
MH  - *Gene Amplification
MH  - *Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Mediastinal Neoplasms/genetics/pathology
MH  - Neuroblastoma/genetics/*pathology
MH  - Survival Rate
EDAT- 2013/09/06 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/09/06 06:00
PHST- 2013/09/06 06:00 [entrez]
PHST- 2013/09/06 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2013.05.003 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2013 May;42(5):299-304. doi: 
      10.3760/cma.j.issn.0529-5807.2013.05.003.