PMID- 24004587
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20211203
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 42
IP  - 5
DP  - 2013 May
TI  - [Activation of mTOR in maldeveloped balloon cells and dysmorphic neurons of type 
      II focal cortical dysplasia].
PG  - 311-5
LID - 10.3760/cma.j.issn.0529-5807.2013.05.005 [doi]
AB  - OBJECTIVE: To investigate whether mammalian target of rapamycin (mTOR) kinase was 
      abnormally activated in maldeveloped balloon cells and dysmorphic neurons of 
      focal cortical dysplasia (FCD) with refractory epilepsy. METHODS: A total of 12 
      archival cases of FCD typeIIwith medically intractable epilepsy treated between 
      2008 and 2010 were retrieved. Perilesional brain tissue was used as control 
      specimens (n = 8). The expression of phosphorylated p-AKT (Ser473), p-mTOR 
      (Ser2448) and p-P70S6K (Thr389) was investigated by imunocytochemistry. RESULTS: 
      The expression of p-AKT (Ser473), p-mTOR (Ser2448) and p-P70S6K (Thr389) was 
      found in meldeveloped balloon cells and dysmorphic neurons of FCD. A weak stain 
      in a small amount of pyramid neurons was also found in the control group. 
      CONCLUSION: Abnormal activation of mTOR in maldeveloped balloon cells and 
      dysmorphic neurons of FCD may be a key molecular mechanism underlying the 
      histological changes and repeated seizures.
FAU - Lin, Kun
AU  - Lin K
AD  - Department of Neurosurgery, First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, China.
FAU - Lin, Yuan-xiang
AU  - Lin YX
FAU - Kang, De-zhi
AU  - Kang DZ
FAU - Ye, Zhong-xing
AU  - Ye ZX
FAU - Wang, Xing-fu
AU  - Wang XF
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nestin)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - Focal cortical dysplasia of Taylor
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Diseases/*metabolism/*pathology
MH  - Child, Preschool
MH  - Epilepsy/metabolism/pathology
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Malformations of Cortical Development/*metabolism/*pathology
MH  - Malformations of Cortical Development, Group I
MH  - Nestin/metabolism
MH  - Neurons/metabolism
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Young Adult
EDAT- 2013/09/06 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/09/06 06:00
PHST- 2013/09/06 06:00 [entrez]
PHST- 2013/09/06 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2013.05.005 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2013 May;42(5):311-5. doi: 
      10.3760/cma.j.issn.0529-5807.2013.05.005.