PMID- 24005132
OWN - NLM
STAT- MEDLINE
DCOM- 20140516
LR  - 20131111
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 554
DP  - 2013 Oct 25
TI  - Functional recovery after transplantation of induced pluripotent stem cells in a 
      rat hemorrhagic stroke model.
PG  - 70-5
LID - S0304-3940(13)00780-5 [pii]
LID - 10.1016/j.neulet.2013.08.047 [doi]
AB  - Transplantation of induced pluripotent stem cells (iPSCs) has shown promising 
      therapeutic effects for ischemic stroke. However, it is not clear if this 
      treatment would promote recovery after intracerebral hemorrhage (ICH). In this 
      study, we investigated the functional outcome of iPSCs transplantation in 
      experimental ICH in rats. IPSCs were derived from an ICH patient's fibroblasts 
      and were injected into the ipsilateral side of ICH in rats. IPSCs transplantation 
      significantly improved the neurological functions after ICH as compared to 
      vehicle and fibroblast injection. The grafted iPSCs migrated into brain tissue 
      around the hematoma, survived after 4 weeks of transplantation, and exhibited the 
      neural cell-specific biomarkers nestin, beta-tubulin, and GFAP. Immunohistochemical 
      staining showed that the densities of brain derived neurophic factors 
      (BDNF)-positive cells and vascular endothelial growth factor (VEGF)-positive 
      cells were significantly increased around the hemorrhagic brain tissues of 
      iPSCs-treated rats. In addition, iPSCs treatment increased the protein expression 
      of BDNF and VEGF in the surrounding region of hematoma. These findings 
      demonstrate that the transplantation of ICH patient-derived iPSCs contributes 
      toward the improved neurological function in experimental ICH rats. The 
      mechanisms are possibly due to neuronal replacement and enhanced secretion of 
      neurophic factors. Our data suggest that transplantation of ICH patient-derived 
      iPSCs may be a therapeutic strategy for hemorrhagic stroke.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Qin, Jie
AU  - Qin J
AD  - Third Department of Neurology, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan 450052, PR China.
FAU - Gong, Guangming
AU  - Gong G
FAU - Sun, Shilei
AU  - Sun S
FAU - Qi, Jing
AU  - Qi J
FAU - Zhang, Huili
AU  - Zhang H
FAU - Wang, Yanlin
AU  - Wang Y
FAU - Wang, Ning
AU  - Wang N
FAU - Wang, Qing Mei
AU  - Wang QM
FAU - Ji, Yan
AU  - Ji Y
FAU - Gao, Yuan
AU  - Gao Y
FAU - Shi, Changhe
AU  - Shi C
FAU - Yang, Bo
AU  - Yang B
FAU - Zhang, Yi
AU  - Zhang Y
FAU - Song, Bo
AU  - Song B
FAU - Xu, Yuming
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130901
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Animals
MH  - Brain/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Differentiation
MH  - Cerebral Hemorrhage/pathology/physiopathology/*therapy
MH  - Epithelial Cells/cytology/transplantation
MH  - Male
MH  - Neural Stem Cells/cytology/*transplantation
MH  - Pluripotent Stem Cells/cytology/*transplantation
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
MH  - Vascular Endothelial Growth Factor A/metabolism
OTO - NOTNLM
OT  - Brain derived neurophic factors (BDNF)
OT  - Induced pluripotent stem cells (iPSCs)
OT  - Intracerebral hemorrhage (ICH)
OT  - Vascular endothelial growth factor (VEGF)
EDAT- 2013/09/06 06:00
MHDA- 2014/05/17 06:00
CRDT- 2013/09/06 06:00
PHST- 2013/07/10 00:00 [received]
PHST- 2013/08/21 00:00 [revised]
PHST- 2013/08/23 00:00 [accepted]
PHST- 2013/09/06 06:00 [entrez]
PHST- 2013/09/06 06:00 [pubmed]
PHST- 2014/05/17 06:00 [medline]
AID - S0304-3940(13)00780-5 [pii]
AID - 10.1016/j.neulet.2013.08.047 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Oct 25;554:70-5. doi: 10.1016/j.neulet.2013.08.047. Epub 2013 
      Sep 1.