PMID- 24005809
OWN - NLM
STAT- MEDLINE
DCOM- 20140905
LR  - 20211021
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 30
IP  - 4
DP  - 2013 Dec
TI  - Overexpression of UHRF1 is significantly associated with poor prognosis in 
      laryngeal squamous cell carcinoma.
PG  - 613
LID - 10.1007/s12032-013-0613-9 [doi]
AB  - The ubiquitin-like with PHD and ring finger domains 1 (UHRF1) has been reported 
      to be essential for cell proliferation and plays a critical role in the 
      development and progression of many human carcinomas. However, its clinical and 
      prognostic significance in laryngeal squamous cell carcinoma (LSCC) remains 
      unclear. In the current study, 60 patients with LSCC were studied. UHRF1 
      expression at mRNA and protein levels was detected by quantitative reverse 
      transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry, 
      respectively, in both tissues of LSCC and corresponding adjacent normal larynx 
      tissues. Statistical analyses were conducted to test the correlations between 
      UHRF1 expression, clinicopathological parameters, and prognosis. qRT-PCR showed 
      that the expression of UHRF1 mRNA in LSCC tissues was significantly higher than 
      that in adjacent normal larynx tissues (P < 0.001). By immunohistochemistry, 
      overexpression of UHRF1 protein was found in 78.3% (47/60) of the LSCC tissues, 
      while there was negative expression in adjacent normal larynx tissues. 
      Furthermore, increased expression of UHRF1 had remarkably positive relationships 
      with smoking (P < 0.001), advanced T stage (P = 0.005) and clinical stage (P = 
      0.044), poor histological differentiation (P = 0.048), while there was no 
      correlations between UHRF1, and sex, age and lymph node metastasis (P > 0.05). 
      Overexpression of UHRF1 was also associated with worse overall survival examined 
      by Kaplan-Meier method (P = 0.036). Multivariate analysis showed that increased 
      expression of UHRF1 was an independent prognostic factor for LSCC (P = 0.013). 
      Therefore, overexpression of UHRF1 may play an important role in the development 
      and progression of LSCC, and UHRF1 might be a useful biomarker for the prognosis 
      of LSCC.
FAU - Pi, Jing-Ting
AU  - Pi JT
AD  - Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical 
      University, No. 1 Youyi Road, Chongqing, 400016, People's Republic of China.
FAU - Lin, Ye
AU  - Lin Y
FAU - Quan, Qiu
AU  - Quan Q
FAU - Chen, Li-Li
AU  - Chen LL
FAU - Jiang, Li-Zhu
AU  - Jiang LZ
FAU - Chi, Wang
AU  - Chi W
FAU - Chen, Hong-Yan
AU  - Chen HY
LA  - eng
PT  - Journal Article
DEP - 20130905
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.3.2.27 (UHRF1 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - CCAAT-Enhancer-Binding Proteins/*biosynthesis/genetics
MH  - Carcinoma, Squamous Cell/*genetics/*metabolism/*pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/*metabolism/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Ubiquitin-Protein Ligases
EDAT- 2013/09/06 06:00
MHDA- 2014/09/06 06:00
CRDT- 2013/09/06 06:00
PHST- 2013/04/23 00:00 [received]
PHST- 2013/05/17 00:00 [accepted]
PHST- 2013/09/06 06:00 [entrez]
PHST- 2013/09/06 06:00 [pubmed]
PHST- 2014/09/06 06:00 [medline]
AID - 10.1007/s12032-013-0613-9 [doi]
PST - ppublish
SO  - Med Oncol. 2013 Dec;30(4):613. doi: 10.1007/s12032-013-0613-9. Epub 2013 Sep 5.