PMID- 24007675
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 121
IP  - 11-12
DP  - 2013 Nov-Dec
TI  - Persistent organic pollutants in Norwegian men from 1979 to 2007: intraindividual 
      changes, age-period-cohort effects, and model predictions.
PG  - 1292-8
LID - 10.1289/ehp.1206317 [doi]
AB  - BACKGROUND: Longitudinal monitoring studies of persistent organic pollutants 
      (POPs) in human populations are important to better understand changes with time 
      and age, and for future predictions. OBJECTIVES: We sought to describe serum POP 
      time trends on an individual level, investigate age-period-cohort effects, and 
      compare predicted polychlorinated biphenyl (PCB) concentrations to measured 
      values. METHODS: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a 
      cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, 
      and birth cohort effects were assessed by graphical analyses and mixed-effect 
      models. We derived the predicted concentrations of four PCBs for each sampling 
      year using the CoZMoMAN model. RESULTS: The median decreases in summed serum POP 
      concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 
      were -22%, -52%, -54%, and -68%, respectively. We observed substantial declines 
      in all POP groups with the exception of chlordanes. Time period (reflected by 
      sampling year) was the strongest descriptor of changes in PCB-153 concentrations. 
      Predicted PCB-153 concentrations were consistent with measured concentrations in 
      the study population. CONCLUSIONS: Our results suggest substantial 
      intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 
      in men from Northern Norway. These changes are consistent with reduced 
      environmental exposure during these 30 years and highlight the relation between 
      historic emissions and POP concentrations measured in humans. Observed data and 
      interpretations are supported by estimates from the CoZMoMAN emission-based 
      model. A longitudinal decrease in concentrations with age was evident for all 
      birth cohorts. Overall, our findings support the relevance of age-period-cohort 
      effects to human biomonitoring of environmental contaminants.
FAU - Nost, Therese Haugdahl
AU  - Nost TH
AD  - Department of Community Medicine, University of Tromso, Tromso, Norway.
FAU - Breivik, Knut
AU  - Breivik K
FAU - Fuskevag, Ole-Martin
AU  - Fuskevag OM
FAU - Nieboer, Evert
AU  - Nieboer E
FAU - Odland, Jon Oyvind
AU  - Odland JO
FAU - Sandanger, Torkjel Manning
AU  - Sandanger TM
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130905
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Age Factors
MH  - Cohort Effect
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Gas Chromatography-Mass Spectrometry
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Models, Statistical
MH  - Norway/epidemiology
MH  - Polychlorinated Biphenyls/blood
MH  - Solid Phase Extraction
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Time Factors
PMC - PMC3855502
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2013/09/07 06:00
MHDA- 2014/07/30 06:00
PMCR- 2013/11/01
CRDT- 2013/09/07 06:00
PHST- 2012/11/26 00:00 [received]
PHST- 2013/08/30 00:00 [accepted]
PHST- 2013/09/07 06:00 [entrez]
PHST- 2013/09/07 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - ehp.1206317 [pii]
AID - 10.1289/ehp.1206317 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2013 Nov-Dec;121(11-12):1292-8. doi: 
      10.1289/ehp.1206317. Epub 2013 Sep 5.