PMID- 24007780
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20131104
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 17
IP  - 3
DP  - 2013 Nov
TI  - The relationship between pro-resorptive inflammatory cytokines and the effect of 
      high dose vitamin D supplementation on their circulating concentrations.
PG  - 693-7
LID - S1567-5769(13)00331-7 [pii]
LID - 10.1016/j.intimp.2013.08.010 [doi]
AB  - Inflammatory/pro-resorptive cytokines and chemokines form part of a complex 
      inter-dependent network and may be influenced by vitamin D. We investigated their 
      inter-relationship and the effect of a loading dose of vitamin D. We measured 
      plasma concentrations of an array of cytokines including tumour necrosis 
      factor-alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, IL-17, IL-8, granulocyte 
      macrophage colony stimulating factor (GM-CSF), and the chemokine monocyte 
      chemoattractant protein-1 (MCP-1). Cytokines, 25 (OH) vitamin D, 1,25 (OH)2 
      vitamin D, the Wnt inhibitor, DKK1 concentrations and bone turnover markers were 
      measured at baseline and 3 months following a bolus dose (300,000 IU) of vitamin 
      D2 in 39 subjects with vitamin D insufficiency. We observed strong correlations 
      between TNF-alpha with GM-CSF (r=0.628, p<0.001), IL-17 (r=0.7, p<0.001) and MCP-1 
      (r=0.5, p=0.001), between IL-1beta with IL-17 (r=0.45, p=0.004) and between the 2 
      chemokines, IL-8 and MCP-1 (r=0.45, p=0.004). A positive correlation was seen 
      between DKK1 and IL-1beta (r=0.35, p=-0.029). Following vitamin D loading at 3 
      months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: 
      r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06). 1,25 (OH)2 vitamin D increased 
      markedly following supplementation. Significant correlations were seen between 25 
      (OH) vitamin D (r=0.4 p=0.016) and 1,25 (OH)2 vitamin D (r=0.39 p=0.02) with 
      plasma CTX (marker of bone resorption) at 3 months. TNF-alpha and IL-1beta increased 
      significantly at 3 months (p<0.05). The close association between several 
      cytokines is influenced by vitamin D status. Acute increases in 1,25 (OH)2 
      vitamin D, achieved with loading doses of vitamin D, lead to increases in 
      pro-resorptive cytokines.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Karim, Yousuf
AU  - Karim Y
AD  - Department of Immunology, St Thomas' Hospital, London SE1 7EH, UK.
FAU - Turner, Charles
AU  - Turner C
FAU - Dalton, Neil
AU  - Dalton N
FAU - Roplekar, Rakshita
AU  - Roplekar R
FAU - Sankaralingam, Arun
AU  - Sankaralingam A
FAU - Ewang, Mfon
AU  - Ewang M
FAU - Fogelman, Ignac
AU  - Fogelman I
FAU - Hampson, Geeta
AU  - Hampson G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130903
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Cytokines)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Aged
MH  - Cytokines/*blood
MH  - Dietary Supplements
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Vitamin D/*administration & dosage/blood/pharmacokinetics
MH  - Vitamin D Deficiency/*blood/drug therapy
MH  - Vitamins/*administration & dosage/blood/pharmacokinetics
OTO - NOTNLM
OT  - Bone resorption
OT  - Chemokines
OT  - Cytokines
OT  - Vitamin D
EDAT- 2013/09/07 06:00
MHDA- 2014/09/25 06:00
CRDT- 2013/09/07 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2013/08/12 00:00 [accepted]
PHST- 2013/09/07 06:00 [entrez]
PHST- 2013/09/07 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - S1567-5769(13)00331-7 [pii]
AID - 10.1016/j.intimp.2013.08.010 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2013 Nov;17(3):693-7. doi: 10.1016/j.intimp.2013.08.010. 
      Epub 2013 Sep 3.