PMID- 2400813
OWN - NLM
STAT- MEDLINE
DCOM- 19901019
LR  - 20091111
IS  - 0007-4551 (Print)
IS  - 0007-4551 (Linking)
VI  - 77
IP  - 5
DP  - 1990
TI  - [Cathepsin D: an independent prognostic factor in cancer of the breast].
PG  - 439-47
AB  - The total amount of cathepsin-D (mature forms and pro-enzyme especially) in the 
      cytosol of 88 breast cancers including 85 primary cancers and 11 axillary lymph 
      node metastasis was measured by way of immuno-radiometric assay. Maximum 
      follow-up is 58 months. Cathepsin-D was found to be independent of clinical and 
      biological parameters including axillary lymph node involvement and oestradiol 
      receptors (RE). Univariate analysis has pointed out a significant linkage between 
      overall survival and cathepsin-D, using a cut-off level of 30 pmol/mg protein 
      which is the most discriminating value. Cathepsin-D appeared to be particularly 
      useful in lymph-node-positive and RE-negative patients but it was not significant 
      in the node-negative population. Multivariate analysis of the overall survival 
      (Cox model) revealed that it was strongly related to oestradiol receptor, lymph 
      node involvement and cathepsin-D.
FAU - Romain, S
AU  - Romain S
AD  - Laboratoire d'oncologie biologique-biopathologie tissulaire, faculte de medecine 
      de Marseille-secteur nord, France.
FAU - Muracciole, X
AU  - Muracciole X
FAU - Varette, I
AU  - Varette I
FAU - Bressac, C
AU  - Bressac C
FAU - Brandone, H
AU  - Brandone H
FAU - Martin, P M
AU  - Martin PM
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La cathepsine-D: un facteur pronostique independant dans le cancer du sein.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
RN  - 0 (Receptors, Estradiol)
RN  - 0 (Receptors, Progesterone)
RN  - EC 3.4.23.5 (Cathepsin D)
SB  - IM
MH  - Adult
MH  - Axilla
MH  - Breast Neoplasms/*analysis/epidemiology/pathology
MH  - Cathepsin D/*analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Receptors, Estradiol/analysis
MH  - Receptors, Progesterone/analysis
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Bull Cancer. 1990;77(5):439-47.