PMID- 24008266
OWN - NLM
STAT- MEDLINE
DCOM- 20140509
LR  - 20130926
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 32
IP  - 5
DP  - 2013 Nov
TI  - alpha-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and 
      increases the levels of brain-derived neurotrophic factor in ovariectomized rats 
      fed a high-fat diet.
PG  - 1179-86
LID - 10.3892/ijmm.2013.1482 [doi]
AB  - Overweight or obesity in post-menopausal women is known to induce metabolic 
      disorders associated with neuroinflammation. alpha-lipoic acid (alpha-LA), which has been 
      clinically used to treat diabetic peripheral neuropathy, has been found to exert 
      anti-inflammatory and neuroprotective effects in patients with Alzheimer's 
      disease (AD). In this study, to investigate the effects of alpha-LA on 
      neuroinflammatory factors and the levels of hippocampal brain-derived 
      neurotrophic factor (BDNF) in ovariectomized rats fed a high-fat diet (HFD), 
      Wistar ovariectomized rats were fed HFD alone or HFD and treated with alpha-LA for 12 
      weeks. Metabolic parameters in serum were detected, real-time polymerase chain 
      reaction (RT-PCR), western blot analysis and ELISA were used to evaluate the 
      levels of inflammatory factors and BDNF in the hippocampus. alpha-LA markedly reduced 
      body weight, the levels of serum total cholesterol (TC) and low-density 
      lipoprotein cholesterol (LDL-C), as well as the levels of leptin and insulin 
      resistance in ovariectomized rats fed HFD. It also significantly increased the 
      levels of serum adiponectin and high-density lipoprotein cholesterol (HDL-C). In 
      the hippocampal tissues of ovariectomized rats fed HFD, the protein and mRNA 
      expression of BDNF was upregulated following the administration of alpha-LA. 
      Conversely, the levels of interleukin 6 (IL-6) and tumour necrosis factor-alpha 
      (TNF-alpha) were decreased following treatment with alpha-LA. These findings demonstrate 
      that alpha-LA significantly increases the expression of BDNF in the hippocampus of 
      obese ovariectomized rats fed HFD, possibly by improving lipid metabolism, 
      enhancing insulin sensitivity and reversing central inflammation.
FAU - Miao, Yulian
AU  - Miao Y
AD  - Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, P.R. China.
FAU - Ren, Jianmin
AU  - Ren J
FAU - Jiang, Ling
AU  - Jiang L
FAU - Liu, Jinbo
AU  - Liu J
FAU - Jiang, Bei
AU  - Jiang B
FAU - Zhang, Xiaoli
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130905
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Female
MH  - Hippocampus/drug effects/*metabolism
MH  - Obesity/*drug therapy/*immunology/metabolism
MH  - Ovariectomy
MH  - Rats
MH  - Thioctic Acid/*therapeutic use
EDAT- 2013/09/07 06:00
MHDA- 2014/05/10 06:00
CRDT- 2013/09/07 06:00
PHST- 2013/06/04 00:00 [received]
PHST- 2013/08/23 00:00 [accepted]
PHST- 2013/09/07 06:00 [entrez]
PHST- 2013/09/07 06:00 [pubmed]
PHST- 2014/05/10 06:00 [medline]
AID - 10.3892/ijmm.2013.1482 [doi]
PST - ppublish
SO  - Int J Mol Med. 2013 Nov;32(5):1179-86. doi: 10.3892/ijmm.2013.1482. Epub 2013 Sep 
      5.