PMID- 24008606
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20181202
IS  - 0026-4806 (Print)
IS  - 0026-4806 (Linking)
VI  - 104
IP  - 4
DP  - 2013 Aug
TI  - A controlled study shows daily intake of 50 mg of French Pine Bark Extract 
      (Pycnogenol(R)) lowers plasma reactive oxygen metabolites in healthy smokers.
PG  - 439-46
AB  - AIM: We investigated a low daily dosage of 50 mg of the antioxidant Pycnogenol 
      for lowering oxidative stress in cigarette smokers who presented with good 
      health. METHODS: A group of 78 smokers were supplemented with 50 mg Pycnogenol 
      over an eight-week period, followed by two weeks cessation. Another 77 smokers 
      took placebo tablets. Plasma reactive oxygen metabolites were detected by d-ROM 
      test and the biological antioxidant potential (BAP) was quantified by photometric 
      analysis of ferric iron reduction to ferrous form. RESULTS: BAP and d-ROM values 
      in the Pycnogenol and placebo group were comparative at trial start. Pycnogenol 
      lowered d-ROM values by 25.3% from baseline 459.4+/-65 to 342.2+/-56 Carr units after 
      2 weeks. At time points 4, 5 and 8 weeks treatment d-ROM values in the Pycnogenol 
      group were significantly lower than in the control group (P<0.05). After 
      cessation of Pycnogenol from week 8 to 10 d-ROM values increased from 288.4+/-32 to 
      381.3+/-39 Carr units. BAP values increased in the Pycnogenol group from baseline 
      1698+/-231 to 2349+/-294 muM after 8 weeks and dropped to 2002+/-203 muM after two weeks 
      washout period. Values in the control group remained largely unaltered with 
      1669+/-311, 1673+/-229 and 1656+/-221 muM, at 0, 8 and 10 weeks, respectively. 
      CONCLUSION: A daily dosage of 50 mg Pycnogenol significantly lowers reactive 
      oxygen species as compared to a placebo-treated equivalent control group.
FAU - Belcaro, G
AU  - Belcaro G
AD  - Irvine 3 Circulation/Vascular Labs, Chieti-Pescara University, Spoltore, Pescara, 
      Italy - cardres@abol.it.
FAU - Hu, S
AU  - Hu S
FAU - Cesarone, M R
AU  - Cesarone MR
FAU - Dugall, M
AU  - Dugall M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Plant Extracts)
RN  - 50JZ5Z98QY (pycnogenols)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - Flavonoids/*administration & dosage
MH  - Health Status
MH  - Humans
MH  - Iron/*metabolism
MH  - Oxidative Stress/*drug effects
MH  - Pinus/chemistry
MH  - Plant Bark/chemistry
MH  - Plant Extracts
MH  - Smoking/*metabolism
EDAT- 2013/09/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/09/07 06:00
PHST- 2013/09/07 06:00 [entrez]
PHST- 2013/09/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - R10Y2013N04A0439 [pii]
PST - ppublish
SO  - Minerva Med. 2013 Aug;104(4):439-46.