PMID- 24009656
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 8
DP  - 2013
TI  - Routine OGTT: a robust model including incretin effect for precise identification 
      of insulin sensitivity and secretion in a single individual.
PG  - e70875
LID - 10.1371/journal.pone.0070875 [doi]
LID - e70875
AB  - In order to provide a method for precise identification of insulin sensitivity 
      from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively 
      simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for 
      the OGTT, which coherently incorporates commonly accepted physiological 
      assumptions (incretin effect and saturating glucose-driven insulin secretion) has 
      been developed. OGTT data from 78 patients in five different glucose tolerance 
      groups were analyzed: normal glucose tolerance (NGT), impaired glucose tolerance 
      (IGT), impaired fasting glucose (IFG), IFG+IGT, and Type 2 Diabetes Mellitus 
      (T2DM). A comparison with the 2011 Salinari (COntinuos GI tract MOdel, COMO) and 
      the 2002 Dalla Man (Dalla Man MOdel, DMMO) models was made with particular 
      attention to insulin sensitivity indices ISCOMO, ISDMMO and kxgi (the insulin 
      sensitivity index for SIMO). ANOVA on kxgi values across groups resulted 
      significant overall (P<0.001), and post-hoc comparisons highlighted the presence 
      of three different groups: NGT (8.62x10(-5)+/-9.36x10(-5) min(-1)pM(-1)), IFG 
      (5.30x10(-5)+/-5.18x10(-5)) and combined IGT, IFG+IGT and T2DM 
      (2.09x10(-5)+/-1.95x10(-5), 2.38x10(-5)+/-2.28x10(-5) and 2.38x10(-5)+/-2.09x10(-5) 
      respectively). No significance was obtained when comparing ISCOMO or ISDMMO 
      across groups. Moreover, kxgi presented the lowest sample average coefficient of 
      variation over the five groups (25.43%), with average CVs for ISCOMO and ISDMMO 
      of 70.32% and 57.75% respectively; kxgi also presented the strongest correlations 
      with all considered empirical measures of insulin sensitivity. While COMO and 
      DMMO appear over-parameterized for fitting single-subject clinical OGTT data, 
      SIMO provides a robust, precise, physiologically plausible estimate of insulin 
      sensitivity, with which habitual empirical insulin sensitivity indices correlate 
      well. The kxgi index, reflecting insulin secretion dependency on glycemia, also 
      significantly differentiates clinically diverse subject groups. The SIMO model 
      may therefore be of value for the quantification of glucose homeostasis from 
      clinical OGTT data.
FAU - De Gaetano, Andrea
AU  - De Gaetano A
AD  - Institute of System Analysis and Informatics (IASI) A. Ruberti, National Research 
      Council (CNR), Rome, Italy.
FAU - Panunzi, Simona
AU  - Panunzi S
FAU - Matone, Alice
AU  - Matone A
FAU - Samson, Adeline
AU  - Samson A
FAU - Vrbikova, Jana
AU  - Vrbikova J
FAU - Bendlova, Bela
AU  - Bendlova B
FAU - Pacini, Giovanni
AU  - Pacini G
LA  - eng
PT  - Journal Article
DEP - 20130829
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Incretins)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Female
MH  - Glucose/metabolism
MH  - Glucose Intolerance
MH  - *Glucose Tolerance Test/methods/standards
MH  - Homeostasis/drug effects
MH  - Humans
MH  - Incretins/pharmacology
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Internet
MH  - Liver/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Software
MH  - Young Adult
PMC - PMC3756988
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/09/07 06:00
MHDA- 2014/04/17 06:00
PMCR- 2013/08/29
CRDT- 2013/09/07 06:00
PHST- 2013/01/17 00:00 [received]
PHST- 2013/06/25 00:00 [accepted]
PHST- 2013/09/07 06:00 [entrez]
PHST- 2013/09/07 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
PHST- 2013/08/29 00:00 [pmc-release]
AID - PONE-D-13-03127 [pii]
AID - 10.1371/journal.pone.0070875 [doi]
PST - epublish
SO  - PLoS One. 2013 Aug 29;8(8):e70875. doi: 10.1371/journal.pone.0070875. eCollection 
      2013.