PMID- 24010339
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 31
IP  - 5
DP  - 2013 May
TI  - [Simultaneous determination of eight furocoumarines in cosmetics by high 
      performance liquid chromatography and verification by liquid 
      chromatography-tandem mass spectrometry].
PG  - 416-22
AB  - A method using high performance liquid chromatography (HPLC) and liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the 
      simultaneous determination of eight furocoumarines (8-hydroxypsoralen, psoralen, 
      isopsoralen, 8-methoxypsoralen, 5-methoxypsoralen, trioxsalen, imperatorin and 
      isoimperatorin) in cosmetics. The cosmetic samples, including cream, lotion, 
      shampoo, powder and lipstick, were supersonically extracted with appropriate 
      solvents. The extract was centrifuged, and the supernatant was filtered through a 
      membrane, and then separated on an Agilent Zorbax SB-Phenyl chromatographic 
      column (250 mm x 4.6 mm, 5 microm) by gradient elution at a flow rate of 1.0 
      mL/min with methanol-acetonitrile-water as mobile phases. The column temperature 
      was set at 30 degrees C. The wavelength of detection was 250 nm. The limits of 
      quantification (LOQs) were 0.25 mg/kg for 8-hydroxypsoralen and 0.5 mg/kg for 
      psoralen, isopsoralen, 8-methoxypsoralen, 5-methoxypsoralen, trioxsalen, 
      imperatorin and isoimperatorin. The recoveries at three spiked levels were in the 
      range of 85.0% - 105.8% with the relative standard deviations (RSDs) of 0.41% - 
      7.90%. The intra-day precision (n=6) was less than 1%, and the inter-day 
      precision (n = 6) was less than 2% for the peak areas of the eight furocoumarines 
      in a mixed standard solution. The method is accurate, simple, rapid and suitable 
      for the determination of the eight furocoumarines in various cosmetic samples.
FAU - Ma, Huijuan
AU  - Ma H
AD  - Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
FAU - Ma, Qiang
AU  - Ma Q
FAU - Li, Wentao
AU  - Li W
FAU - Meng, Xianshuang
AU  - Meng X
FAU - Li, Jingrui
AU  - Li J
FAU - Bai, Hua
AU  - Bai H
FAU - Jiao, Yang
AU  - Jiao Y
FAU - Zhang, Xiaoli
AU  - Zhang X
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Cosmetics)
RN  - 0 (Furocoumarins)
RN  - 0ZMV066080 (isoimperatorin)
RN  - 2009-24-7 (xanthotoxol)
RN  - 4FVK84C92X (5-Methoxypsoralen)
RN  - CZZ080D7BD (angelicin)
RN  - K713N25C78 (imperatorin)
RN  - KTZ7ZCN2EX (Ficusin)
RN  - U4VJ29L7BQ (Methoxsalen)
RN  - Y6UY8OV51T (Trioxsalen)
SB  - IM
MH  - 5-Methoxypsoralen
MH  - *Chromatography, High Pressure Liquid
MH  - Cosmetics/*analysis
MH  - Ficusin
MH  - Furocoumarins/*analysis
MH  - Methoxsalen/analogs & derivatives
MH  - *Tandem Mass Spectrometry
MH  - Trioxsalen
EDAT- 2013/09/10 06:00
MHDA- 2015/07/15 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3724/sp.j.1123.2012.12006 [doi]
PST - ppublish
SO  - Se Pu. 2013 May;31(5):416-22. doi: 10.3724/sp.j.1123.2012.12006.