PMID- 24010716
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20211021
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 12
IP  - 1
DP  - 2013 Sep 8
TI  - Association between perfluoroalkyl substances and thyroid stimulating hormone 
      among pregnant women: a cross-sectional study.
PG  - 76
LID - 10.1186/1476-069X-12-76 [doi]
AB  - BACKGROUND: Perfluoroalkyl substances (PFASs) are a group of highly persistent 
      chemicals that are widespread contaminants in wildlife and humans. Exposure to 
      PFAS affects thyroid homeostasis in experimental animals and possibly in humans. 
      The objective of this study was to examine the association between plasma 
      concentrations of PFASs and thyroid stimulating hormone (TSH) among pregnant 
      women. METHODS: A total of 903 pregnant women who enrolled in the Norwegian 
      Mother and Child Cohort Study from 2003 to 2004 were studied. Concentrations of 
      thirteen PFASs and TSH were measured in plasma samples collected around the 18th 
      week of gestation. Linear regression models were used to evaluate associations 
      between PFASs and TSH. RESULTS: Among the thirteen PFASs, seven were detected in 
      more than 60% of samples and perfluorooctane sulfonate (PFOS) had the highest 
      concentrations (median, 12.8 ng/mL; inter-quartile range [IQR], 10.1 
      -16.5 ng/mL). The median TSH concentration was 3.5 (IQR, 2.4 - 4.8) muIU/mL. 
      Pregnant women with higher PFOS had higher TSH levels. After adjustment, with 
      each 1 ng/mL increase in PFOS concentration, there was a 0.8% (95% confidence 
      interval: 0.1%, 1.6%) rise in TSH. The odds ratio of having an abnormally high 
      TSH, however, was not increased, and other PFASs were unrelated to TSH. 
      CONCLUSIONS: Our results suggest an association between PFOS and TSH in pregnant 
      women that is small and may be of no clinical significance.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Health and Human Services, National Institute of Environmental 
      Health Sciences, National Institutes of Health, Durham, NC, USA. 
      wangy13@niehs.nih.gov.
FAU - Starling, Anne P
AU  - Starling AP
FAU - Haug, Line S
AU  - Haug LS
FAU - Eggesbo, Merete
AU  - Eggesbo M
FAU - Becher, Georg
AU  - Becher G
FAU - Thomsen, Cathrine
AU  - Thomsen C
FAU - Travlos, Gregory
AU  - Travlos G
FAU - King, Debra
AU  - King D
FAU - Hoppin, Jane A
AU  - Hoppin JA
FAU - Rogan, Walter J
AU  - Rogan WJ
FAU - Longnecker, Matthew P
AU  - Longnecker MP
LA  - eng
GR  - 1-F30-ES022126-01/ES/NIEHS NIH HHS/United States
GR  - 1UO1 NS 047537-01/NS/NINDS NIH HHS/United States
GR  - N01-ES-85433/ES/NIEHS NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130908
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Alkanes)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkanes/*blood
MH  - Chromatography, High Pressure Liquid
MH  - Cross-Sectional Studies
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Immunoassay
MH  - Linear Models
MH  - Norway
MH  - Odds Ratio
MH  - Pregnancy
MH  - Tandem Mass Spectrometry
MH  - Thyrotropin/*blood
MH  - Young Adult
PMC - PMC3847507
EDAT- 2013/09/10 06:00
MHDA- 2014/07/01 06:00
PMCR- 2013/09/08
CRDT- 2013/09/10 06:00
PHST- 2013/04/17 00:00 [received]
PHST- 2013/09/03 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
PHST- 2013/09/08 00:00 [pmc-release]
AID - 1476-069X-12-76 [pii]
AID - 10.1186/1476-069X-12-76 [doi]
PST - epublish
SO  - Environ Health. 2013 Sep 8;12(1):76. doi: 10.1186/1476-069X-12-76.