PMID- 24011150
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20130909
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 29
IP  - 9
DP  - 2013 Sep
TI  - [Therapeutic effect and hepatotoxicity of Tripterygium wilfordii compound recipe 
      gel on adjuvant-induced arthritis rat].
PG  - 914-8
AB  - OBJECTIVE: To investigate the therapeutic effect and the impact on liver function 
      of different-dose Tripterygium wilfordii compound recipe gel (TWCG) for external 
      use on adjuvant-induced arthritis (AA) rats. METHODS: Freund's adjuvant-induced 
      arthritis rats were dressed with different doses of TWCG, voltaren as positive 
      control and blank gel as blank control. The ankle swelling degrees were 
      evaluated; the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 
      (IL-4) were detected by ELISA; the levels of matrix metalloproteinase-3 (MMP-3) 
      in ankle cartilage were determined by immunohistochemical method; the serum 
      levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 
      were tested with the automatic biochemical analyzer. RESULTS: Compared with the 
      model group (dressed with blank gel), the ankle swelling degrees in TWCG groups 
      and voltaren group were significantly reduced (P<0.05); the levels of TNF-alpha 
      markedly decreased and IL-4 increased in sera (P<0.05); the content of MMP-3 in 
      ankle joint tissues was significantly reduced (P<0.05). The effects in high-dose 
      TWCG group and median-dose TWCG group were better than that in voltaren group and 
      low-dose TWCG group (P<0.05). However, the levels of ALT and AST were not 
      statistically different among the groups (P>0.05). CONCLUSION: TWCG has obvious 
      anti-inflammatory and detumescence effects on AA rat. It can protect cartilage 
      tissue effectively without significant hepatotoxicity.
FAU - Zhou, Jie
AU  - Zhou J
AD  - Department of Integrated Traditional Chinese and Western Medicine, Chongqing 
      Medical University, Chongqing, China. zhoujie200924@163.com
FAU - Liu, Yuefeng
AU  - Liu Y
FAU - He, Kai
AU  - He K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Gels)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Arthritis, Experimental/*drug therapy/immunology/physiopathology
MH  - Aspartate Aminotransferases/blood
MH  - Female
MH  - Gels
MH  - Interleukin-4/blood
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Tripterygium/toxicity
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2013/09/10 06:00
MHDA- 2013/11/19 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Sep;29(9):914-8.