PMID- 24012073
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20231110
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Print)
IS  - 1056-4993 (Linking)
VI  - 22
IP  - 4
DP  - 2013 Oct
TI  - The prodrome and clinical risk for psychotic disorders.
PG  - 557-67
LID - S1056-4993(13)00025-4 [pii]
LID - 10.1016/j.chc.2013.04.002 [doi]
AB  - The psychosis prodrome offers great promise for identifying neural mechanisms 
      involved in psychotic disorders and offers an opportunity to implement empirical 
      interventions to delay, and ultimately ameliorate, illness onset. This article 
      summarizes the literature on individuals in the putatively prodromal phase of 
      psychosis/deemed at clinical high risk (CHR) for psychosis onset. Standardized 
      measurement and manifestation of the CHR syndromes are discussed, followed by 
      empirical findings that highlight the psychological deficits and biological 
      abnormalities seen in CHR syndromes and psychotic disorders. Current 
      controversies surrounding the diagnosis of CHR syndromes and issues related to 
      the treatment of CHR individuals are also presented.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Goulding, Sandra M
AU  - Goulding SM
AD  - Mental Health and Development Program, Department of Psychology, Emory 
      University, 36 Eagle Row, Room 270, Atlanta, GA 30322, USA. Electronic address: 
      sandra.m.goulding@emory.edu.
FAU - Holtzman, Carrie W
AU  - Holtzman CW
FAU - Trotman, Hanan D
AU  - Trotman HD
FAU - Ryan, Arthur T
AU  - Ryan AT
FAU - Macdonald, Allison N
AU  - Macdonald AN
FAU - Shapiro, Daniel I
AU  - Shapiro DI
FAU - Brasfield, Joy L
AU  - Brasfield JL
FAU - Walker, Elaine F
AU  - Walker EF
LA  - eng
GR  - L30 MH095165/MH/NIMH NIH HHS/United States
GR  - T32 MH082745/MH/NIMH NIH HHS/United States
GR  - U01MHMH081988/PHS HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130618
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
MH  - Adolescent
MH  - Brain/pathology/physiopathology
MH  - Cognition Disorders/epidemiology
MH  - Diagnosis, Differential
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - *Disease Progression
MH  - Disease Susceptibility
MH  - Evoked Potentials/physiology
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Predictive Value of Tests
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - *Psychotic Disorders/diagnosis/epidemiology/pathology
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC4140174
MID - NIHMS568668
OTO - NOTNLM
OT  - Clinical high risk
OT  - Prodrome
OT  - Psychosis
OT  - Schizophrenia
EDAT- 2013/09/10 06:00
MHDA- 2014/03/19 06:00
PMCR- 2014/08/21
CRDT- 2013/09/10 06:00
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PHST- 2014/08/21 00:00 [pmc-release]
AID - S1056-4993(13)00025-4 [pii]
AID - 10.1016/j.chc.2013.04.002 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):557-67. doi: 
      10.1016/j.chc.2013.04.002. Epub 2013 Jun 18.