PMID- 24012102
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20201206
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 151
IP  - 2
DP  - 2013 Nov
TI  - High insulin-like growth factor-1 in patients with bipolar I disorder: a trait 
      marker?
PG  - 738-743
LID - S0165-0327(13)00630-7 [pii]
LID - 10.1016/j.jad.2013.07.041 [doi]
AB  - OBJECTIVES: Neurotrophic factors exert substantial effects on the central nervous 
      system. The present study investigates the roles of insulin-like growth factor-1 
      (IGF-1), beta-nerve growth factor (beta-NGF), and brain-derived neurotrophic factor 
      (BDNF) in bipolar disorder. METHODS: Baseline levels of culture-stimulated IGF-1, 
      beta-NGF, and BDNF were compared in 116 patients with bipolar I disorder and 123 
      healthy controls. Neurotrophic factors were also compared in patients before and 
      after 6 weeks of pharmacotherapy. A multivariate logistic regression analysis was 
      used to investigate the influence of the neurotrophic factors analyzed in 
      quartile form, in relation to confounding variables, such as age, sex, and body 
      mass index. RESULTS: IGF-1 was significantly higher in patients (mean=514.57, 
      SD=259.78) than in healthy controls (mean=316.82, SD=270.00, p<0.0001) at 
      baseline. Furthermore, higher levels of IGF-1 substantially increased the risk 
      for bipolar I disorder. IGF-1 level was not significantly changed at 6-weeks 
      (mean=506.41, SD=313.66). No changes in BDNF or beta-NGF-1 levels were found 
      following the 6-week treatment period. IGF-1 and beta-NGF were negatively correlated 
      in healthy controls, but not in patients. Severity of manic symptoms was not 
      associated with any of the neurotrophic factors. LIMITATIONS: We did not measure 
      cortisol, growth hormone, or IGF-1 receptors. This study is cross-sectional in 
      design. CONCLUSIONS: Elevated IGF-1 levels may be a trait marker for bipolar 
      disorder. Further studies are needed to thoroughly investigate the role of IGF-1 
      in relation to other neuroendocrine factors and biological markers for bipolar 
      disorder.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Kim, Yong-Ku
AU  - Kim YK
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Na, Kyoung-Sae
AU  - Na KS
AD  - Department of Psychiatry, Gachon University Gil Medical Center, 1198, Guwol-dong, 
      Namdong-Gu, Incheon, Republic of Korea. Electronic address: ksna13@gmail.com.
FAU - Hwang, Jung-A
AU  - Hwang JA
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Yoon, Ho-Kyoung
AU  - Yoon HK
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Lee, Heon-Jeong
AU  - Lee HJ
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Hahn, Sang-Woo
AU  - Hahn SW
AD  - Department of Psychiatry, College of Medicine, Soonchunhyang University, Seoul, 
      Republic of Korea.
FAU - Lee, Bun-Hee
AU  - Lee BH
AD  - Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, 
      Republic of Korea.
FAU - Jung, Han-Yong
AU  - Jung HY
AD  - Department of Psychiatry, College of Medicine, Soonchunhyang University, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130822
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood/drug therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Brain-derived neurotrophic factor
OT  - Insulin-like growth factor-1
OT  - Nerve growth factor
OT  - Neurotrophin
EDAT- 2013/09/10 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/07/28 00:00 [revised]
PHST- 2013/07/30 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - S0165-0327(13)00630-7 [pii]
AID - 10.1016/j.jad.2013.07.041 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Nov;151(2):738-743. doi: 10.1016/j.jad.2013.07.041. Epub 
      2013 Aug 22.