PMID- 24012391
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20181202
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 29
IP  - 11-12
DP  - 2013 Nov-Dec
TI  - Effects of resveratrol on obesity-related inflammation markers in adipose tissue 
      of genetically obese rats.
PG  - 1374-80
LID - S0899-9007(13)00228-1 [pii]
LID - 10.1016/j.nut.2013.04.014 [doi]
AB  - OBJECTIVE: The aim of this study was to examine whether resveratrol might 
      represent a promising therapeutic tool with which to combat adipose tissue 
      chronic inflammation in a model of genetic obesity and to link its 
      anti-inflammatory activity with its effect on body fat reduction. METHODS: Twenty 
      6-wk-old male Zucker (fa/fa) rats were randomly distributed into two experimental 
      groups. Resveratrol (RSV) was given orally (15 mg/kg body weight/d in RSV group) 
      by means of an orogastric catheter for 6 wk. Enzyme activities were measured 
      spectrophotometrically or fluorimetrically. Gene and protein expressions were 
      analyzed by reverse transcriptase polymerase chain reaction and Western blot 
      respectively. Cytokine concentrations and the activity of nuclear factor 
      kappa-light-chain-enhancer of activated beta cells (NF-kappaB) were measured by using 
      commercial kits. RESULTS: RSV reduced the weight of internal adipose tissues. In 
      epididymal depot glucose-6P-dehydrogenase, acetyl-CoA carboxylase activities, as 
      well as lipoprotein lipase expression and activity were reduced by RSV. The 
      expression of hormone-sensitive lipase was increased, and that of the cluster of 
      differentiation 36 was reduced. Serum concentrations of tumor necrosis factor-alpha, 
      monocyte chemoattractant protein 1, and C-reactive protein were lower in the 
      RSV-treated group than in the control group. Protein expression of interleukin-6 
      and the activity of NF-kappaB, were decreased by RSV. CONCLUSION: The present results 
      provide evidence that fatty acid uptake and lipolysis are metabolic pathways 
      involved in the response of adipose tissue to RSV. This polyphenol modulates 
      plasma cytokine levels partially by reducing macrophage infiltration in adipose 
      tissue and inhibiting NF-kappaB activity.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Gomez-Zorita, Saioa
AU  - Gomez-Zorita S
AD  - Nutrition and Obesity Group, Department of Nutrition and Food Science, University 
      of the Basque Country, Vitoria, Spain; CIBERobn Physiopathology of Obesity and 
      Nutrition, Institute of Health Carlos III, Madrid, Spain.
FAU - Fernandez-Quintela, Alfredo
AU  - Fernandez-Quintela A
FAU - Lasa, Arrate
AU  - Lasa A
FAU - Hijona, Elizabeth
AU  - Hijona E
FAU - Bujanda, Luis
AU  - Bujanda L
FAU - Portillo, Maria P
AU  - Portillo MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130905
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Adiponectin)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Fatty Acids)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Stilbenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Acetyl-CoA Carboxylase/metabolism
MH  - Adiponectin/blood
MH  - Adipose Tissue/*drug effects/metabolism
MH  - Animals
MH  - Body Weight/drug effects
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/blood
MH  - Fatty Acids/administration & dosage/pharmacokinetics
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Inflammation/blood/etiology/*metabolism
MH  - Interleukin-6/blood
MH  - Lipolysis/drug effects
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Obesity/complications/*metabolism
MH  - Rats
MH  - Rats, Zucker
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Adipose tissue
OT  - Inflammation
OT  - Lipases
OT  - Lipogenesis
OT  - Resveratrol
OT  - Zucker rat
EDAT- 2013/09/10 06:00
MHDA- 2014/05/23 06:00
CRDT- 2013/09/10 06:00
PHST- 2012/11/27 00:00 [received]
PHST- 2013/04/17 00:00 [revised]
PHST- 2013/04/19 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - S0899-9007(13)00228-1 [pii]
AID - 10.1016/j.nut.2013.04.014 [doi]
PST - ppublish
SO  - Nutrition. 2013 Nov-Dec;29(11-12):1374-80. doi: 10.1016/j.nut.2013.04.014. Epub 
      2013 Sep 5.