PMID- 24012459
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20220311
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 150
IP  - 2-3
DP  - 2013 Nov
TI  - Social cognition as a mediator between neurocognition and functional outcome in 
      individuals at clinical high risk for psychosis.
PG  - 542-6
LID - S0920-9964(13)00451-9 [pii]
LID - 10.1016/j.schres.2013.08.015 [doi]
AB  - In schizophrenia, neurocognition, social cognition and functional outcome are all 
      inter-related, with social cognition mediating the impact that impaired 
      neurocognition has on functional outcome. Less clear is the nature of the 
      relationship between neurocognition, social cognition and functional outcome in 
      individuals at clinical high risk (CHR) for psychosis. 137 CHR participants 
      completed a neurocognitive test battery, a battery of social cognition tasks and 
      the Social Functioning Scale. Confirmatory factor analysis showed that all social 
      cognition tasks were reliable and valid measures of the latent variable. The path 
      from neurocognition to functioning was statistically significant (standardized 
      coefficient beta=0.22, p<0.01). The path from social cognition to functioning was 
      also statistically significant (beta=0.27, p<0.05). In the mediation model the 
      bootstrapping estimate revealed a nonsignificant indirect effect that was the 
      association of social cognition with neurocognition and with functional outcome 
      (beta=0.20, 95% CI=-0.07 to 0.52, p=0.11). However, social cognition was 
      significantly associated with neurocognition (beta=0.80, p<0.001) and the path from 
      neurocognition to functioning was no longer significant as soon as the mediator 
      (social cognition) was entered into the mediation model (beta=0.02, p=0.92). All of 
      the model fit indices were very good. Unlike what has been observed with 
      psychotic patients, social cognition does not seem to mediate the pathway from 
      neurocognition to functional outcome when assessed with a measure of social 
      attainment in individuals at CHR for psychosis.
CI  - (c) 2013.
FAU - Barbato, Mariapaola
AU  - Barbato M
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Alberta, Canada. Electronic address: mbarbato@ucalgary.ca.
FAU - Liu, Lu
AU  - Liu L
FAU - Penn, David L
AU  - Penn DL
FAU - Keefe, Richard S E
AU  - Keefe RS
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Woods, Scott W
AU  - Woods SW
FAU - Addington, Jean
AU  - Addington J
LA  - eng
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01MH06634-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130905
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Cognition Disorders/*etiology
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*psychology
MH  - *Social Behavior
MH  - Statistics as Topic
MH  - Young Adult
PMC - PMC3839963
MID - NIHMS518384
OTO - NOTNLM
OT  - Clinical high risk
OT  - Functional outcome
OT  - Mediation
OT  - Neurocognition
OT  - Schizophrenia
OT  - Social cognition
COIS- Conflict of interest There are no conflicts of interest for any of the authors 
      with respect to the data in this paper or for the study.
EDAT- 2013/09/10 06:00
MHDA- 2014/06/21 06:00
PMCR- 2014/11/01
CRDT- 2013/09/10 06:00
PHST- 2013/05/23 00:00 [received]
PHST- 2013/08/08 00:00 [revised]
PHST- 2013/08/12 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - S0920-9964(13)00451-9 [pii]
AID - 10.1016/j.schres.2013.08.015 [doi]
PST - ppublish
SO  - Schizophr Res. 2013 Nov;150(2-3):542-6. doi: 10.1016/j.schres.2013.08.015. Epub 
      2013 Sep 5.