PMID- 24012585
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 12
DP  - 2013 Dec
TI  - Associations of HLA class I antigen specificities and haplotypes with disease 
      progression in HIV-1-infected Hans in Northern China.
PG  - 1636-42
LID - S0198-8859(13)00512-0 [pii]
LID - 10.1016/j.humimm.2013.08.287 [doi]
AB  - The human leukocyte antigen (HLA) allele frequencies, which differ among various 
      ethnic populations, may result in population-specific effects on HIV-1 disease 
      progression. No large-scale study has yet been conducted on the Chinese 
      population. In this study, HLA class I antigen specificities were determined in a 
      cohort including 105 long-term non-progressors (LTNPs) and 321 typical 
      progressors (TPs), who were recruited from HIV-1-infected Northern Han Chinese, 
      to determine the associations between certain HLA types and HIV-1 disease 
      progression. The frequencies of HLA class I specificities and haplotypes among 
      the two groups were compared using binary logistic stepwise regression. Results 
      showed that HLA-A( *)30-B( *)13-C( *)06 (OR = 0.387, P = 0.019) and B( *)67 (OR = 
      0.134, P = 0.005) were associated with a long-term non-progressing condition, and 
      C( *)01 (OR = 2.539, P = 0.050) was overrepresented in TPs after adjusting for 
      non-genetic factors (sex, age, the location of patients, HIV subtype and the 
      route of infection). The influence of HLA homozygosity on HIV disease progression 
      was also analyzed. However, homozygosity at HLA-A, HLA-B or HLA-C conferred no 
      observable disadvantage in our study population (P = 0.730, 0.246 and 0.445, 
      respectively). These findings suggest that the host's genetics make important 
      contributions to HIV viral control and may help to develop peptide-based vaccines 
      for this population.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Key Laboratory of AIDS Immunology of the Ministry of Health, Department of 
      Laboratory Medicine, The First Hospital of China Medical University, Shenyang, 
      China.
FAU - Zhao, Bin
AU  - Zhao B
FAU - Han, Xiaoxu
AU  - Han X
FAU - Wang, Zhe
AU  - Wang Z
FAU - Liu, Baogui
AU  - Liu B
FAU - Lu, Chunming
AU  - Lu C
FAU - Zhang, Min
AU  - Zhang M
FAU - Liu, Jing
AU  - Liu J
FAU - Chen, Ou
AU  - Chen O
FAU - Hu, Qinghai
AU  - Hu Q
FAU - Jiang, Fanming
AU  - Jiang F
FAU - Shang, Hong
AU  - Shang H
LA  - eng
PT  - Journal Article
DEP - 20130905
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - HIV Infections/*genetics/*immunology/virology
MH  - HIV-1/genetics/*immunology
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - AIDS
OT  - CTL
OT  - HIV-1
OT  - HLA
OT  - KIR
OT  - LD
OT  - LTNP
OT  - NK
OT  - PBD
OT  - PCR-SSP
OT  - RP
OT  - TP
OT  - VL
OT  - acquired immunodeficiency syndrome
OT  - cytotoxic T lymphocyte
OT  - human immunodeficiency virus type-1
OT  - human leukocyte antigen
OT  - killer Ig-like receptor
OT  - linkage disequilibrium
OT  - long-term non-progressor
OT  - natural killer
OT  - paid blood donations
OT  - polymerase chain reaction sequence-specified primer
OT  - rapid progressor
OT  - typical progressor
OT  - viral load
EDAT- 2013/09/10 06:00
MHDA- 2014/07/19 06:00
CRDT- 2013/09/10 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/07/17 00:00 [revised]
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - S0198-8859(13)00512-0 [pii]
AID - 10.1016/j.humimm.2013.08.287 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Dec;74(12):1636-42. doi: 10.1016/j.humimm.2013.08.287. Epub 
      2013 Sep 5.