PMID- 24013234
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20211021
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Print)
IS  - 0304-8608 (Linking)
VI  - 159
IP  - 2
DP  - 2014 Feb
TI  - Cell cycle perturbations induced by human herpesvirus 6 infection and their 
      effect on virus replication.
PG  - 365-70
LID - 10.1007/s00705-013-1826-0 [doi]
AB  - In this study, we demonstrate that infection of HSB-2 cells with human 
      herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M 
      phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins 
      indicated that the levels of cyclins A2, B1, and E1 were increased in 
      HHV-6-infected cells, but there was no difference in cyclin D1 levels between 
      mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M 
      phase arrest in cells infected by HHV-6 provided favorable conditions for viral 
      replication.
FAU - Li, Lingyun
AU  - Li L
AD  - Department of Developmental Genetics, Nanjing Medical University, Nanjing, 
      210029, Jiangsu, China.
FAU - Gu, Bin
AU  - Gu B
FAU - Zhou, Feng
AU  - Zhou F
FAU - Chi, Jing
AU  - Chi J
FAU - Feng, Dongju
AU  - Feng D
FAU - Xie, Fangyi
AU  - Xie F
FAU - Wang, Fang
AU  - Wang F
FAU - Ma, Changyan
AU  - Ma C
FAU - Li, Meng
AU  - Li M
FAU - Wang, Jinfeng
AU  - Wang J
FAU - Yao, Kun
AU  - Yao K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130908
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Cell Cycle Proteins)
SB  - IM
MH  - *Cell Cycle
MH  - Cell Cycle Proteins/analysis
MH  - Cell Line
MH  - Herpesvirus 6, Human/*physiology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - T-Lymphocytes/*physiology/*virology
MH  - *Virus Replication
PMC - PMC7086940
EDAT- 2013/09/10 06:00
MHDA- 2014/03/29 06:00
PMCR- 2020/03/23
CRDT- 2013/09/10 06:00
PHST- 2013/02/20 00:00 [received]
PHST- 2013/07/08 00:00 [accepted]
PHST- 2013/09/10 06:00 [entrez]
PHST- 2013/09/10 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 1826 [pii]
AID - 10.1007/s00705-013-1826-0 [doi]
PST - ppublish
SO  - Arch Virol. 2014 Feb;159(2):365-70. doi: 10.1007/s00705-013-1826-0. Epub 2013 Sep 
      8.